no-image silhouette

Greeshma Agasthya

Research Scientist in AI for Healthcare

Greeshma Agasthya is a biomedical engineer with experience in medical imaging research and modeling and simulation for radiation dosimetry. She is currently a research scientist in the advanced computing for health sciences section at Oak Ridge National Laboratory . Greeshma has developed and used multi-scale modeling and simulations of the human body for virtual clinical trials, radiation dosimetry and optimization of medical imaging systems for cancer applications. She has worked on artificial intelligence (AI) for cancer surveillance, predicting disease outcomes, and clinical decision support. Through her career she has worked with medical physicists, radiologists, cardiologists, computer engineers and statisticians to solve several healthcare challenges. She has worked on imaging modalities including neutron imaging, x-ray radiography, computed tomography (CT) and tomosynthesis systems for liver, lung, breast and prostate cancer applications. She has also worked with magnetic resonance imaging (MRI) and echocardiography for cardiac imaging and clinical outcomes research. 

Greeshma received her doctorate in Biomedical Engineering from Duke University and completed her postdoctoral training at Emory University's Winship Cancer Institute. At ORNL, Greeshma is working with the VA to develop multivariate time-series analysis based prediction models for metastatic prostate cancer. She is working on a BER project to develop spatio-temporal radiation exposure trajectories to study the effect of low-dose radiation on human health. She is leading projects with university collaborators in multi-modal analytics for mental health and neurosurgery planning. She is interested in leveraging high performance computing and AI to solve challenges in medical imaging and biomedical modeling and simulations. 


  • Greeshma Agasthya (PI), “AI-enabled surrogate models for predicting brain-shift in real-time”. Awarded $190,000 from Laboratory Directed Research and Development Seed Fund at Oak Ridge National Lab for 1 year March 2021 – March 2022
  • Greeshma Agasthya (PI), “High performance computing and AI-based pediatric mental health trajectories”. Recommended for funding $3,875,514 as part of a strategic partnership program with Cincinnati Children’s Hospital Medical Center over a period of 5-years (2021 – 2026)
  • Greeshma Agasthya (PI), “Multiscale Computational Framework for Precision Dosimetry”. Awarded $500,000 from Laboratory Directed Research and Development Fund for Accelerating Radiotherapeutics Through Advanced Molecular Constructs Initiative over a period of 2 years (2021 – 2023)