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Publication

Elucidating the coordination chemistry of the radium ion for targeted alpha therapy...

Publication Type
Journal
Journal Name
Chemical Communications
Publication Date
Page Numbers
9938 to 9941
Volume
58
Issue
71

The coordination chemistry of Ra2+ is poorly defined, hampering efforts to design effective chelators for 223Ra-based targeted alpha therapy. Here, we report the complexation thermodynamics of Ra2+ with the biomedically-relevant chelators DOTA and macropa. Our work reveals the highest affinity chelator to date for Ra2+ and advances our understanding of key factors underlying complex stability and selectivity for this underexplored ion.