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Liquid vortex capture mass spectrometry (LVC-MS) was coupled with single cell printing to enable mass spectrometric analysis of cells with high throughput and sensitivity.
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Laser capture microdissection-Liquid Vortex Capture-Mass Spectrometry (LMD-LVC-MS) was used to identify and chemically measure small and large cells automatically.
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Vibrational sum frequency generation was used to study the liquid extraction of Co2+ using DEHPA ligands at the buried hexadecane/aqueous interface. Unique H-bonding structures are found to drive assembly and ultimately dictate what species are extracted.
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A new time-domain approach to chemical imaging, coherent anti-stokes Raman scattering (CARS) in a total internal reflection geometry, was developed to map the spatial variation of molecular species in complex environments.
Overview
The Mass Spectrometry and Laser Spectroscopy group is a diverse team of experts in analytical and physical chemistry with an extensive range of state-of-the-art and novel instrumentation used for fundamental and applied research based around mass spectrometry and laser spectroscopy of complex systems.
Much of our current research focuses on:
- Multimodal imaging for chemical imaging of plant-microbial interactions, interfaces, tissues and other complex systems
- Nonlinear laser spectroscopy and microscopy of electronic and molecular processes in complex materials
- Mass spectrometry for high throughput and sensitive chemical characterization
We specialize in developing and applying the next generation of technologies to probe and chemically characterize complex systems.
Group Capabilities
Mass Spectrometry
- High Resolution Orbitrap MS
- High Resolution Time-of-Flight MS
- Triple Quadrupole MS
- Ion Mobility Time-of-Flight
Ultrafast and Surface Specific Spectroscopy
- Vibrational Sum Frequency Generation
- Electronic Sum Frequency Generation
- Transient Absorption Spectroscopy
Liquid Extraction-Surface Sampling
- Open-Port Sampling Interface
- DropletProbe
- FlowProbe
- Liquid-Vortex Capture
Nonlinear Optical Imaging
- Transient Absorption Microscopy
- Coherent anti-Stokes Raman Microscopy
- Sum Frequency and Second Harmonic Generation Microscopy
- Multiphoton Fluorescence Microscopy
Our Group In The News
Polymers get caught up in love-hate chemistry of oil and water
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Single Cell Mass Spectrometry Technology wins R&D100 Award
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ORNL video highlights MSLS single cell analysis technology
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Ben Doughty Wins DOE BES Early Career Award
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Open Port Sampling Interface Wins Technology Transfer Award
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MSLS Group Wins Federal Laboratory Consortium award for OPSI Invention
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TouchExpress OPSI Featured in The Analytical Scientist
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Advion Introduces TouchExpress Open Port Sampling Interface for their expression® Compact Mass Spectrometer (CMS)
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Open Port Sampling Interface (OPSI) Licensed
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