Mass Spectrometry and Laser Spectroscopy

Mass Spectrometry and Laser Spectroscopy

The Mass Spectrometry and Laser Spectroscopy group is a diverse team of experts in analytical chemistry with an extensive range of state-of-the-art and novel instrumentation used for fundamental and applied research based around mass spectrometry and laser spectroscopy. Three current core research focus areas are: (1) Multimodal imaging for chemical cartography of material interfaces; (2) Nonlinear laser spectroscopy and microscopy of electronic and molecular processes in complex materials; (3) Mass spectrometry-based proteomics focused on microbial and plant systems.

Spatially Resolving


The Kalanchoë genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism

Crassulacean acid metabolism (CAM) is a water-use efficient adaptation of photosynthesis that has evolved independently many times in diverse lineages of flowering plants. We hypothesize that...

Integrated omics analyses reveal the details of metabolic adaptation of Clostridium thermocellum to lignocellulose-derived growth inhibitors released during the deconstruction of switchgrass

Clostridium thermocellum is capable of solubilizing and converting lignocellulosic biomass into ethanol. Although much of the work-to-date has centered on characterizing this microbe’s growth on...

Online, Absolute Quantitation of Propranolol from Spatially Distinct 20- and 40-μm Dissections of Brain, Liver, and Kidney Thin Tissue Sections by Laser Microdissection–Liquid Vortex Capture–Mass Spectrometry

Spatial resolved quantitation of chemical species in thin tissue sections by mass spectrometric methods has been constrained by the need for matrix-matched standards or other arduous calibration...


Our research on multimodal imaging comprises development of new instrumentation concept and the fundamental study, evaluation and ultimately application of new high spatial resolution technologies, compromised of atomic force microscopy, optical microscopy and spectroscopy, and mass spectrometry components for physical and chemical characterization of material interfaces important within the DOE’s energy research portfolio (e.g. solar energy utilization, energy storage, catalysis, bioenergy, and chemical sensors), drug discovery, and other biomedical research. Research on nonlinear laser spectroscopy and microscopy broadly aims to develop new approaches for the fundamental understanding of energy and charge flow in heterogeneous media that undergo novel chemical and electronic transformations on molecular time and length scales. Particular focus is given to the areas central to DOE’s mission, including applications to light harvesting materials, catalysis, self-assembly and organization, and energy storage. Finally, out research on mass spectrometry-based proteomics involves development and deployment of high performance liquid chromatography- tandem mass spectrometry capabilities for examining the molecular machinery of a variety of environmental host-microbe ecosystems, in an effort to provide integrated “omics” capabilities for systems biology research. Particular focus is given to bioenergy research, microbial-driven environmental carbon-nitrogen cycling in soil systems, and human microbiome investigations.