Leighton Coates STS Instrument Systems Manager Contact 865.574.4620 | coatesl@ornl.gov All Publications Effects of SARS-CoV-2 Main Protease Mutations at Positions L50, E166, and L167 Rendering Resistance to Covalent and Noncovalent Inhibitors Second Target Station Project: STS Cross-Directorate Workshop on Hydrogen Fuel Visualizing the Active Site Oxyanion Loop Transition Upon Ensitrelvir Binding and Transient Dimerization of SARS-CoV-2 Main Protease New Opportunities for Neutrons in Environmental and Biological Sciences Second Target Station Project: STS/PSD/ESTD Workshop on Batteries and Energy Storage Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors AI-Accelerated Design of Targeted Covalent Inhibitors for SARS-CoV-2 A realistic guide misalignment model for the Second Target Station instruments at the Spallation Neutron Source ORNL Second Target Station Project: Biological & Environmental Science Workshop Unmasking the Conformational Stability and Inhibitor Binding to SARS-CoV-2 Main Protease Active Site Mutants and Miniprecursor Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain Cryo neutron crystallography demonstrates influence of RNA 2′-OH orientation on conformation, sugar pucker and water structure EWALD: A Macromolecular Diffractometer for the Second Target Station The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature Hit Expansion of a Noncovalent SARS-CoV-2 Main Protease Inhibitor Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease Detector needs for STS instruments Cryotrapping peroxide in the active site of human mitochondrial manganese superoxide dismutase crystals for neutron diffraction High-Throughput Virtual Screening and Validation of a SARS-CoV-2 Main Protease Noncovalent Inhibitor Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease Michaelis-like complex of SARS-CoV-2 main protease visualized by room-temperature X-ray crystallography Toho-1 β-lactamase: backbone chemical shift assignments and changes in dynamics upon binding with avibactam Second Target Station Instrument Systems Research and Development Plan Structural plasticity of the selectivity filter in a nonselective ion channel... Pagination Current page 1 Page 2 Page 3 Next page ›› Last page Last » Key Links Google Scholar ORCID Second Target Station Pittsburgh Diffraction Society Google Scholar
