Andrii Y Kovalevskyi

Senior R&D Scientist

Dr. Andrey Kovalevsky is a structural biologist, biochemist and instrument scientist on the ORNL IMAGINE at HFIR and MaNDi at SNS neutron crystallographic instruments. Dr. Kovalevsky studied organic chemistry and crystallography at Kharkov State University, Kharkov, Ukraine, receiving M.Sc. degree with Honors, and worked as a Research Assistant at the Nesmeyanov Institute of Organoelement Compounds, Moscow, Russia. He received his Ph.D. in Physical Chemistry in 2003 from the University at Buffalo, the State University of New York, working with Prof. Philip Coppens on the development of photocrystallographic technique. He studied macromolecular crystallography, biochemistry and molecular biology while working as a Postdoctoral Associate at Georgia State University. He held a Director’s Postdoctoral Fellowship while at Los Alamos National Laboratory (LANL) working with Dr. Paul Langan in neutron protein crystallography. Prior to joining ORNL, he held a position as a Staff Scientist at LANL working on the Protein Crystallography Station. Dr. Kovalevsky has authored over 180 peer-reviewed publications; his research has been funded by LANL and ORNL Laboratory Directed Research & Development programs, the US Department of Energy, and the National Institutes of Health.

Dr. Kovalevsky’s current research focuses on structure-dynamics-function relationships in enzymes, structure-assisted drug design, and drug resistance, utilizing macromolecular X-ray/neutron crystallography, neutron vibrational spectroscopy, and other biophysical methods in combination with biomolecular simulations.