Abstract
Differential Mobility Spectrometry (DMS), which ionizes analyte and uses asymmetric field waveforms to identify the ions, is increasingly used for detection of trace chemicals. In this work, we reveal the linear relation between DMS compensation voltage and the nonlinear mobility coefficient () and consider mobility difference induced by clustering in low-field and de-clustering in high field. A program for Monte Carlo simulation of ion transport in practical DMS analyzers has been developed. Practical factors considered in this simulation mainly include a realistic sine-based asymmetric waveform and the clustering and de-clustering associated with this asymmetric waveform. Using this program, DMS compensation spectra, RF-CV dispersion plots, and transport efficiencies are predicted. Some experiments are done for validating the simulations and show consistency with the predictions.