The Heating, Ventilation, Air-Conditioning and Refrigeration (HVAC&R) industry is currently transitioning away from high global warming potential (GWP) hydrofluorocarbon (HFC) refrigerants. However, many lower-GWP alternatives are flammable. Current safety codes restrict use of all flammable refrigerants; revision of the codes is needed to facilitate wider use of flammable alternatives. Hence, information is needed to enable reliable estimates of safe charge limits for flammable refrigerant options for different HVAC&R applications. A reduced-order-model (ROM) was developed and validated to help estimate safe charge limits based on computational fluid dynamics (CFD) simulations of refrigerant releases in a single room for a range of parameters. Validation of the ROM vs. the CFD results showed good general agreement for mean refrigerant concentration. The average error was 0.67% with a maximum error of 15%.