Kevin L Weiss Senior Technical Staff Contact 865.805.7388 | weisskl@ornl.gov All Publications Unusual zwitterionic catalytic site of SARS–CoV-2 main protease revealed by neutron crystallography... Substrate Binding Stiffens Aspartate Aminotransferase by Altering the Enzyme Picosecond Vibrational Dynamics A nucleotide-dependent oligomerization of the Escherichia coli replication initiator DnaA requires residue His136 for remodeling of the chromosomal origin Pressure and Temperature Effects on the Formation of Aminoacrylate Intermediates of Tyrosine Phenol-lyase Demonstrate Reaction Dynamics Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex Intrinsically Disordered Protein Exhibits Both Compaction and Expansion under Macromolecular Crowding Substrate Binding Induces Conformational Changes in a Class A β-lactamase That Prime It for Catalysis "To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation Solution Structure of an Intramembrane Aspartyl Protease via Small Angle Neutron Scattering... Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme Active-Site Protonation States in an Acyl-Enzyme Intermediate of a Class A β-Lactamase with a Monobactam Substrate Long‐Range Electrostatics‐Induced Two‐Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site... Domain crossover in the reductase subunit of NADPH-dependent assimilatory sulfite reductase Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutro... Structural characterization of an intrinsically disordered protein complex using integrated small-angle neutron scattering and computing SCOMAP-XD: atomistic deuterium contrast matching for small-angle neutron scattering in biology... Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2 An N⋯H⋯N low-barrier hydrogen bond preorganizes the catalytic site of aspartate aminotransferase to facilitate the second half-reaction Neutron scattering maps the higher-order assembly of NADPH-dependent assimilatory sulfite reductase Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease Cryotrapping peroxide in the active site of human mitochondrial manganese superoxide dismutase crystals for neutron diffraction Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease Fed-batch production of deuterated protein in Escherichia coli for neutron scattering experimentation... Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication Toho-1 β-lactamase: backbone chemical shift assignments and changes in dynamics upon binding with avibactam Pagination Current page 1 Page 2 Page 3 Next page ›› Last page Last » Key Links ORCID Organizations Neutron Sciences Directorate Neutron Scattering Division Large Scale Structures Section Biological Labeling and Scattering Group User Facilities Center for Structural Molecular Biology High Flux Isotope Reactor Spallation Neutron Source