Vinyl Dimethyl Azlactone-Containing Copolymers: Towards Bio-Inspired Surfaces/Polymer-Protein Conjugates
By:
Messman, Jamie M; Banaszak, Abigail; Barrninger, Joshua; Mays, Jimmy W; Kilbey Ii, Sidney M
Page Number:
77-88
Book Title:
Advances in Intelligent Coatings Design� Proceedings of the Thirty-Fourth Annual International Waterborne, High-Solids, and Powder Coatings Symposium
Publication Date:
November 2008
Publisher Location:
The University of Southern Mississippi, Hattiesburg, Mississippi, United States of America
Conference Name:
The Waterborne Symposium Advances in Intelligent Coatings Design
Conference Location:
New Orleans, Louisiana, United States of America
Abstract
Stimuli-responsive, vinyl dimethyl azlactone/vinyl pyrrolidone (VDMA/VP) copolymers have been prepared using free radical polymerization techniques. These copolymers are subsequently the basis for the design of polymer brushes where the system is composed of a polystyrene (PS) block and a VDMA/VP copolymer block. Copolymers have been prepared using reversible addition fragmentation chain transfer (RAFT) polymerization technique. Using a solvent that is selective for the VDMA/VP block, these PS-block-P[VDMA/VP] copolymers can be preferentially adsorbed at the solid-fluid interface through the PS block to form a polymer "brush". Because VDMA is known to quantitatively react with amines, exposure of the copolymer to a solution containing amino acids (e.g. glycine) yields a bio-functionalized polymer brush. In this paper we will report on the synthesis and characterization of VDMA/VP copolymers including compositional analysis using FTIR and NMR spectroscopies.