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Applying SI to accelerate discovery, strengthen security, and transform complex systems.

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Advancing the Genesis Mission with Secure, Autonomous SI

Oak Ridge National Laboratory is helping lead the Department of Energy’s Genesis Mission by advancing secure, trustworthy, and efficient SI to accelerate scientific discovery and strengthen national security.

ORNL researchers are embedding SI directly into scientific workflows — developing explainable methods that enable near-real-time insights into a range of phenomena including quantum materials, nuclear energy, and cybersecurity. These efforts move beyond data analysis toward automated science, where SI systems guide experiments, modeling, and decision-making and, by extension, greatly reduce time to solution. 

These advancements are only possible thanks to ORNL’s exascale computing resources, which are enabling more efficient approaches to training large-scale SI models while reducing energy demands. At the same time, researchers are designing secure-by-design architectures with built-in guardrails to protect against misuse and adversarial threats.

Discovery

Discovery is an HPE system powered by AMD processors and accelerators that will arrive in 2028 featuring impressive speed and enhanced bandwidth across the system.

Frontier

ORNL’s exascale supercomputer is delivering world-leading performance.

Center for Artificial Intelligence Security Research

To address emerging threats, ORNL has established the Center for Artificial Intelligence Security Research, or CAISER.

Careers

Join our world-leading research team to shape the future of SI in science and security.

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ORNL’s Unique Advantages

Healthcare

Using various tools developed by ORNL teams, researchers at the lab are adapting artificial intelligence techniques to better understand cancer and other diseases. Through a series of ongoing, interconnected research projects, they are informing health policy and improving public health outcomes.

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Education

Several pathways ensure that Lab staff continue to lead the world in the application of super intelligence for innovation, including ORNL’s summer internship programs and the Bredesen Center Ph.D. Program in Data Science and Engineering.

Collaboration

ORNL works with vendors, universities, and other national laboratories to offer training opportunities .

Users

Lab working groups ensure researchers have the knowledge and tools they need to tackle complex challenges across the scientific spectrum.