December 2018

Journal

Neutron scattering in the biological sciences: progress and prospects

By:
Ashkar, Rana A; Bilheux, Hassina ; Bordallo, Heliosa; Briber, Robert M; Callaway, David; Cheng, Xiaolin ; Chu, Xiang-Qiang; Curtis, Joseph; Dadmun, Mark; Fenimore, Paul; Fushman, David; Gabel, Frank R; Gupta, Kushol ; Heberle, Frederick A; Heinrich, Frank ; Hong, Liang; Katsaras, John ; Kelman, Zvi ; Kharlampieva, Eugenia P; Kneller, Gerald; Kovalevskyi, Andrii Y; Krueger, Susan ; Langan, Paul A; Lieberman, Raquel; Liu, Yun; Losche, Mathias; Lyman, Edward R; Mao, Yimin M; Marino, John A; Mattos, Carla; Meilleur, Flora ; Moody, Peter C; Nickels, Jonathan; Odell, William E; O'Neill, Hugh M; Perez-Salas, Ursula A; Peters, Judith; Petridis, Loukas ; Sokolov, Alexei P; Stanley, Christopher B; Wagner, Norman; Weinrich, Michael; Weiss, Kevin L; Wymore, Troy; Zhang, Yang; Smith, Jeremy C
Journal Name:
Acta Crystallographica Section D: Structural Biology
Page Number:
1129-1168
Volume:
74
Issue Number:
n/a
Publication Date:
December 2018
View DOI Listing:
https://doi.org/10.1107/S2059798318017503

Abstract

The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.

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