August 2011

Journal

A method for preparing sodium acrylate-d3, a useful and stable precursor for deuterated acrylic monomers

By:
Yang, Jun ; Hong, Kunlun ; Bonnesen, Peter V
Journal Name:
Journal of Labelled Compounds and Radiopharmaceuticals
Page Number:
743-748
Volume:
54
Issue Number:
12
Publication Date:
August 2011
View DOI Listing:
https://doi.org/10.1002/jlcr.1915

Abstract

A convenient and economical method for converting propiolic acid to sodium acrylate-d3 is described. Successive D/H exchange of the alkyne proton of sodium propiolate (prepared from propiolic acid) using D2O affords sodium propiolate-d having up to 99 atom% D. Sodium propiolate-d can be partially reduced to sodium acrylate-d3 with 90% conversion and 89% yield, using D2 and the Lindlar catalyst with control of reaction parameters to maximize conversion while minimizing over reduction.


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