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A generic biokinetic model for noble gases with application to radon...

by Richard W Leggett, James Marsh, Demetrio Gregoratto, Eric Blanchardon
Publication Type
Journal
Journal Name
Journal of Radiological Protection
Publication Date
Page Numbers
413 to 432
Volume
33
Issue
2

The International Commission for Radiological Protection (ICRP) currently uses a “dose conversion coefficient” to calculate effective dose per unit exposure to radon and its progeny. The coefficient is derived by dividing the detriment associated with unit exposure to radon, as estimated from epidemiological studies, by the detriment per unit effective dose, as estimated mainly from atomic bomb survivor data and animal studies. In a recent statement the ICRP indicated that future guidance on exposure to radon and its progeny will be developed in the same way as guidance for any other radionuclide. That is, intake of radon and progeny will be limited on the basis of effective dose coefficients derived from biokinetic and dosimetric models. This paper proposes a biokinetic model for systemic (absorbed) radon for use in the calculation of dose coefficients for inhaled or ingested radon. The model is based largely on physical laws governing transfer of a non-reactive and soluble gas between materials. Model predictions are shown to be consistent with results of controlled studies of the fate of internally deposited radon in human subjects.