Purification of berkelium-249 (249Bk) at Oak Ridge National Laboratory requires a multi-step process with Bk Finishing as the final step. The current multi-process takes 6–7 months, including ~ 3 months spent on Bk Finishing. Recent trials of using columns of either LN resin or MP-1 anion exchange resin adsorbing the tetravalent 249Bk4+ in 8M HNO3-0.5M NaBrO3, followed by eluting impurities (e.g. Ce4+, Cf3+) and stripping 249Bk resulted in a new dual column method of selectively separating 249Bk from other trans-curium elements and fission product impurities, which is proposed to replace the current Bk Finishing with higher Bk purification efficiency and shorter processing period. This paper displays the experimental results and describes the dual column method with relevant chemistry issues.