Scientific Achievement
We describe how the confinement of lipid vesicles in micropillar arrays can result in the formation of nonuniform lipid membranes.
Significance and Impact
A better understanding of membrane formation at the microscale will aid in advancing disease detection, drug discovery and tissue engineering.
Research Details
– Micropillars with different heights were fabricated with photolithography and reactive ion etching.
– Lipid mobility and ordering on micropillars were determined from fluorescence intensity profiles and fluorescence recovery after photobleaching (FRAP) using laser scanning confocal fluorescence microscopy.
F. Liu, S. M. Abel, L. Collins, B. R. Srijanto, R. Standaert, J. Katsaras, C. P. Collier, “Geometry-Dependent Nonequilibrium Steady-State Diffusion and Adsorption of Lipid Vesicles in Micropillar Arrays,” Adv. Mater. Interfaces 1900054 (2019). DOI: 10.1002/admi.201900054
