Scientific Achievement
Diisobutylene Maleic Acid Copolymer (DIBMA) is shown to co-assemble with lipid molecules into a nanodisc structure.
Significance and Impact
The DIBMA nanodisc can be completely contrast matched and is therefore an ideal membrane-mimetic substrate for studying the otherwise difficult to characterize integral membrane proteins that are involved in many important cellular processes.
Research Details
- DIBMA/lipid assembly structure was studied with contrast variation small angle neutron scattering.
- The newly developed DENSS algorithm was used to derive neutron scattering length density distribution and particle structure.
“Structure of Diisobutylene Maleic Acid Copolymer (DIBMA) and its Lipid Particle as A ‘Stealth’ Membrane Mimetic for Membrane Protein Research,”
Guo, Rong, Sumner, Jacob, Qian, Shuo,
ACS Applied Bio Materials 4 (6), 4760-4768, (2021).
DOI: https://doi.org/10.1021/acsabm.0c01626
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