Biological and Nanoscale Systems

Biological and Nanoscale Systems

The Biological and Nanoscale Systems Group focuses on the characterization, integration and adaptation of natural and synthetic systems across multiple length scales. A continuing emphasis is to characterize and understand how natural systems are organized at the nanoscale and how this organization contributes to biological function.

Biological and Nanoscale Systems


Development of a high efficiency integration system and promoter library for rapid modification of Pseudomonas putida KT2440

Pseudomonas putida strains are highly robust bacteria known for their ability to efficiently utilize a variety of carbon sources, including aliphatic and aromatic hydrocarbons. Recently, P. putida...

Root bacterial endophytes alter plant phenotype, but not physiology

Plant traits, such as root and leaf area, influence how plants interact with their environment and the diverse microbiota living within plants can influence plant morphology and physiology. Here, we...

β-(1,3)-Glucan Unmasking in Some Candida albicans Mutants Correlates with Increases in Cell Wall Surface Roughness and Decreases in Cell Wall Elasticity

Candida albicans is among the most common human fungal pathogens, causing a broad range of infections, including life-threatening systemic infections. The cell wall of C. albicans is the interface...

Capabilities & Research Areas

This interdisciplinary group focuses on technology development with specific interests in biological imaging, biocompatible micro- and nanofabrication techniques, and high throughput screening technologies. Current imaging projects evaluate microbial systems and seek to trace the location and quantity of membrane proteins, to identify interacting proteins, and to confirm biochemical networks. Nanotechnology projects are centered on mimicking the physical and chemical characteristics of biological cells, developing biocompatible patterning techniques, and adapting biological routes to nanoscale material fabrication.The group maintains comprehensive resources in molecular biology and in molecular and cellular imaging and leverages off of the advanced fabrication capabilities of ORNL’s Center for Nanophase Materials Sciences.