COVID-19
ORNL is in the fight against COVID-19
In the race to identify solutions to the COVID-19 pandemic, researchers at the Department of Energy’s Oak Ridge National Laboratory are joining the fight by applying expertise in computational science, advanced manufacturing, data science and neutron science.
Computational science. ORNL’s Summit, the world’s most powerful supercomputer, is accelerating COVID-19-related research through the new COVID-19 High Performance Computing Consortium. At least 2,286,200 Summit node-hours have been allocated to 22 Covid-19 related projects to date. Twelve of these allocations are from the HPC Covid Consortium, of which we are a founding member. These computing allocations are aimed at improving scientists’ understanding of the virus’ structure and biology with the goal of developing targeted therapies and vaccines.
Neutron scattering. ORNL is providing remote, rapid access to its advanced neutron source facilities, the Spallation Neutron Source and the High Flux Isotope Reactor, to support research related to the COVID-19 pandemic. As part of the search for effective diagnostics and therapies, rapid access will be awarded for experiments to address necessary science and technical questions identified by the COVID-19 research community.
Advanced manufacturing. ORNL researchers are exploring efforts such as new designs for reusable masks and face shields and a breath-sampling whistle for at-home testing. This includes using additive manufacturing to significantly reduce tooling cost and production time; coordinating with both medical suppliers and the manufacturing supply chain to speed and expand production capabilities; and establishing plans to reverse engineer and rapidly manufacture and distribute tooling for critical components.
Pandemic modeling and analysis. Argonne, Oak Ridge, Los Alamos and Sandia national laboratories are collaborating to develop an integrated COVID-19 pandemic monitoring, modeling and analysis expertise, leveraging the labs’ collective scalable data and computing.
ATOM collaboration. ORNL is part of a multi-lab effort within the Accelerating Therapeutics for Opportunities in Medicine, or ATOM, consortium, a public-private partnership focused on dramatically reducing the time it takes to discover and develop new medicines through the application of leading-edge technologies like machine learning and artificial intelligence.
Many ORNL research projects studying COVID-19 are supported by the DOE Office of Science’s National Virtual Biotechnology Laboratory with funding provided by the Coronavirus CARES Act.
News
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Neutron Science
- Neutrons reveal unpredicted binding between SARS-CoV-2, hepatitis C antiviral drug
- Journeying ‘inside’ the COVID-19 viral protein to attack a weak point
- Neutrons catch shape-shifting coronavirus protein complex in the act
- ORNL offers rapid access to neutron sources for COVID-19 research
- Oak Ridge neutron facilities ramping up research to combat COVID-19
- Scientists investigate solutions for building cell membrane defense against COVID-19
- Neutrons probe biological materials for insights into COVID-19 virus infection
- Investigators seek material evidence to arrest COVID-19 inflammation
- Neutrons probe molecular behavior of proposed COVID-19 drug candidates
- X-ray study explores potential of hepatitis C drugs to treat COVID-19
- Neutrons chart atomic map of COVID-19’s viral replication mechanism
- X-rays size up protein structure at the ‘heart’ of COVID-19 virus
- COVID-19 forces ORNL researchers to take STEM education online
- ORNL is in the fight against COVID-19
Biology and Environment
- X-ray study explores potential of hepatitis C drugs to treat COVID-19
- NellOne Therapeutics partners with ORNL on COVID-19 drug delivery system
- X-rays size up protein structure at the ‘heart’ of COVID-19 virus
- Omar Demerdash: Russell Fellow, drug discovery researcher shifts to national effort to find COVID-19 solutions
Clean Energy
- Kashif Nawaz: Redesigning building equipment for carbon capture and beyond
- Transportation – Gauging pandemic impact
Materials
- Powerful polymers: ORNL study provides new insights into N95’s COVID-19 filter efficiency
- Nanoscience – Blowing the whistle on COVID-19
- ORNL industry collaboration enables job growth, N95 mask production in Florida
- Advanced manufacturing innovation helps industry in COVID-19 fight
- ORNL is in the fight against COVID-19
Isotopes
National Security
Partnerships