Understanding Complex Biological Systems

The Biosciences Division at Oak Ridge National Laboratory conducts transformative research to uncover new insights about complex biological systems and their interactions with the environment. With expertise and special facilities spanning genomics, computational biology, microbiology, microbial ecology, biophysics, structural biology, and plant sciences, the division advances Department of Energy (DOE) missions in energy and environmental research.

Leveraging cutting-edge technologies and collaborative approaches, we develop solutions for bioenergy, human health, and the environment. Our scientists …

  • apply high performance computing to discover complex genetic traits critical to bioenergy, resilient crops, and more
  • leverage ORNL’s neutron science capabilities to increase understanding of cell structure and intracell interactions
  • develop biodesign tools to engineer safer, more reliable, and more productive plant-microbe systems
  • inform development of new disease diagnostics and treatments through fundamental science discoveries
  • examine the exchange of energy, information, and materials between plants and microbial communities, providing new insights into ecosystem dynamics
  • accelerate the development of new biotechnologies in collaboration with industry
Austin Conte, a University of Tennessee Ph.D. student, works in Lab 215, Building 1520, at Oak Ridge National Laboratory.

Biodesign and Systems Biology Section

Scientists working in the Biodesign and Systems Biology section at Oak Ridge National Laboratory aim to uncover the fundamental mechanisms that shape biological responses—and use this knowledge to design solutions that enhance plant performance, optimize microbial interactions, and improve bioengineering processes.

Biocomputing and Information Section

The Biocomputing and Information Section combines advanced computing, data science and molecular-scale research to deepen understanding of complex biological systems. Its researchers develop computational models, high-performance simulations and predictive tools while improving how scientific data are integrated, communicated and accessed. Together, these capabilities accelerate discoveries in biology, biotechnology, energy and environmental science.

Bioimaging and Analytics Section

Scientists working in the Bioimaging and Analytics section at Oak Ridge National Laboratory focus on delivering innovative solutions to biological and environmental systems science measurement challenges.

“We push the boundaries of biology to develop transformative solutions that advance biotechnology, resilience, and biosecurity.”

Jesse Labbé, Biosciences Division Director

A Generative Pre-trained Transformer for Genomic Photosynthesis

IDeA: Intelligent Design Assistant for Enzyme Discovery and Biosynthetic Pathway Optimization

SMART Plant Field Systems

Bio-Scales

Our Science in Action

Contact

Jesse Labbé

Division Director, Biosciences Division

[email protected]