Computational capability has been developed to calculate sensitivity coefficients of generalized responses with respect to cross-section data in the SCALE code system. The focus of this paper is the implementation of generalized perturbation theory (GPT) for one-dimensional and two-dimensional deterministic neutron transport calculations. GPT is briefly summarized for computing sensitivity coefficients for reaction rate ratio responses within the existing framework of the TSUNAMI sensitivity and uncertainty (S/U) analysis code package in SCALE. GPT provides the capability to analyze generalized responses related to reactor analysis, such as homogenized cross-sections, relative powers, and conversion ratios, as well as measured experimental parameters such as 28ρ (epithermal/thermal 238U capture rates) in thermal benchmarks and fission ratios such as 239Pu(n,f)/235U(n,f) in fast benchmarks. The S/U analysis of these experimental integral responses can be used to augment the existing TSUNAMI S/U analysis capabilities for system similarity assessment and data adjustment. S/U analysis is provided for boiling water reactor pin cell as part of the Organization for Economic Cooperation and Development Uncertainty Analysis in Modeling benchmark.