Harnessing Analytical Technologies to Quantify Biological Function at the Molecular Scale
Scientists working in the Bioimaging and Analytics section at Oak Ridge National Laboratory focus on delivering innovative solutions to biological and environmental systems science measurement challenges. The team strives to understand the molecular composition, physical structure, and biological function of living systems across different scales and time frames.
Data-Driven Analysis
The section serves as a focal point for the convergence of unique laboratory resources related to computing, engineering, and the physical sciences. Nanotechnology-based tools, neutron science-based measurements, quantum-based technologies, and new data analysis approaches are leveraged to reveal quantifiable biological system characteristics.
Develop New Approaches
Other major research focuses on biological and chemical imaging. Scientists develop engineered habitats and advanced imaging techniques specifically designed to facilitate live imaging and efficient sample characterization. These approaches provide unprecedented access to real-time biological processes within living organisms.
Understand and Characterize
Key research focuses on the advancement and application of high-performance mass spectrometry methods, nuclear magnetic resonance, and laser-based spectroscopies. These techniques enable researchers to thoroughly characterize metals, metabolites, proteins, and other biomolecules, revealing complex molecular interactions and processes. By achieving detailed chemical characterization, scientists gain insights critical to unraveling biological functions and dynamics.
Produce Sound Results
These advanced methods significantly enhance the accuracy of biological measurements and analyses, empowering scientists to precisely interrogate biological pathways and functions across systems scales.
“We utilize diverse measurement approaches and emerging nano- and quantum-based technologies — combined with sophisticated data analysis strategies — to quantify biological characteristics across physical and temporal scales.”
Mitch Doktycz Bioimaging and Analytics Section
Biomass Imaging and Characterization Group
Employing laser and magnetic resonance spectroscopy to characterize plant biomass, biomass conversion processes for fuels, processes for reusing and upcycling polymers, and producing bioderived materials, including 3D-printed polymers and composites
Developing and deploying high-performance mass spectrometry techniques for analytical characterization and chemical imaging of non-volatile biomolecules, including proteomes and metabolomes
