In this issue...
HGP on Fast Track
Joint Genome Institute Exceeds Goal
Sequencing with BACs
with STCs and STSs
of BAC Clones and STC Data
Resource Success Story
Hunt SNPs for Variation, Disease
Sequencing the Human Genome?
Progress in Science
Promotes Remote Access to Instrumentation
Private-Sector Sequencing Project
In the News
Delivers C. elegans Sequence
Sequence Entire Genomes? Worm's Eye View
BER Research Update
1998 Human Genome Awards Announced
Consortium for Functional Genomics
Merges Offices, Web Sites
Microbial Genomes Searchable
Releases Chlorobium tepidum Sequence
MGP Abstracts Online
Ethical, Legal, and Social Issues
and Educational Resources
Lander, Genetics in the 21st Century
Rothstein, Genetic Privacy
Wilson, Gene Therapy Present & Future
Walters, Ethical Issues in Gene Therapy
Files on NPR, Internet
Course for Biology Teachers
at Proteins to Understand Expression
for Protein Analysis
100 Award Goes to LANL's SOLVE
Awards Proteomics Grant to Axys
coli Proteome Database
Genetics in Medicine
Organization for Rare Disorders
of Genetics to Medicine: New Website
Genetics Web Site
Website Offers Education in New Genetics
of Genetic Risks 2nd Edition
Research Genomics Online
Database Operations Restored
Silico Biology: Bioinformatics Journal
Methods Book Available
Programs at Sanger
Licenses Gene Logic Software
Database at LANL
at Jackson Laboratory
Database on Web
Web, Other Resources, Publications
Oakland Workshop Website
to Human Chromosomes
Office of Science Grants and Contracts
National Service Award Fellowships
Technologies for Molecular Analysis
Netork for Large-Scale Mouse Sequencing
Genomic Technology Development
Genome Research Funding
Meeting Calendars & Acronyms
and Biotechnology Meetings
Courses and Workshops
Five-Year Research Goals of the U.S. Human Genome Project
October 1, 1998 to September 30, 2003
Note: For more on the Five Year Research Goals, see the website.
Human DNA Sequence
- Achieve coverage of at least 90% of the genome in a working draft based on mapped clones by the end of 2001.
- Finish one-third of the human DNA sequence by the end of 2001.
- Finish the complete human genome sequence by the end of 2003.
- Make the sequence totally and freely accessible.
- Continue to increase the throughput and reduce the cost of current sequencing technology.
- Support research on novel technologies that can lead to significant improvements in sequencing technology.
- Develop effective methods for the advanced development and introduction of new sequencing technologies into the sequencing process.
Human Genome Sequence Variation
- Develop technologies for rapid, large-scale identification and/or scoring of single nucleotide polymorphisms and other DNA sequence variants.
- Identify common variants in the coding regions of the majority of identified genes during this five-year period.
- Create a SNP map of at least 100,000 markers.
- Develop the intellectual foundations for studies of sequence variation.
- Create public resources of DNA samples and cell lines.
Functional Genomics Technology
- Generate sets of full-length cDNA clones and sequences that represent human genes and model organisms.
- Support research on methods for studying functions of nonprotein-coding sequences.
- Develop technology for comprehensive analysis of gene expression.
- Improve methods for genome-wide mutagenesis.
- Develop technology for large-scale protein analyses.
- Complete the sequence of the roundworm C. elegans genome by 1998.
- Complete the sequence of the fruitfly Drosophila genome by 2002.
- Develop an integrated physical and genetic map for the mouse, generate additional mouse cDNA resources, and complete the sequence of the mouse genome by 2008.
- Identify other useful model organisms and support appropriate genomic studies.
Ethical, Legal, and Social Issues
- Examine issues surrounding the completion of the human DNA sequence and the study of human genetic variation.
- Examine issues raised by the integration of genetic technologies and information into health care and public health activities.
- Examine issues raised by the integration of knowledge about genomics and gene-environment interactions in non-clinical settings.
- Explore how new genetic knowledge may interact with a variety of philosophical, theological, and ethical perspectives.
- Explore how racial, ethnic, and socioeconomic factors affect the use, understanding, and interpretation of genetic information; the use of genetic services; and the development of policy.
Bioinformatics and Computational Biology
- Improve content and utility of databases.
- Develop better tools for data generation, capture, and annotation.
- Develop and improve tools and databases for comprehensive functional studies.
- Develop and improve tools for representing and analyzing sequence similarity and variation.
- Create mechanisms to support effective approaches for producing robust, exportable software that can be widely shared.
Training and Manpower
- Nurture the training of scientists skilled in genomics research.
- Encourage the establishment of academic career paths for genomic scientists.
- Increase the number of scholars who are knowledgeable in both genomic and genetic sciences and in ethics, law, or the social sciences.
The electronic form of the newsletter may be cited in the following style:
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Human Genome Program, U.S. Department of Energy, Human Genome News (v10n1-2).