The Genesis Mission is a national initiative led by the Department of Energy and its 17 national laboratories to build the world’s most powerful scientific platform to accelerate discovery science, strengthen national security, and drive energy innovation. It does so by enabling AI-driven, exascale-powered advances that enhance America’s energy innovation, global competitiveness, and security.
By connecting computing, data, and experimental facilities into a unified system, Genesis accelerates discovery and shortens the path from research to real-world impact, strengthening U.S. leadership in energy, security, and advanced technology.
The Genesis Mission Consortium brings together the Department of Energy, national laboratories, industry, and academia to accelerate breakthrough science and technology across disciplines.
Explore how ORNL is applying its unique strengths as part of the Genesis Mission to address critical national challenges across energy, security, and advanced science. Through the integration of ORNL's computing facilities, data, and experimental capabilities, the laboratory is accelerating discovery and real-world impact.
Discovery is an HPE system powered by AMD processors and accelerators that will be delivered in 2028 and will advance discoveries via high-performance modeling and simulation integrated with AI, while charting the path to the convergence of high-performance computing (HPC), AI and quantum computing.
The Lux AI cluster, to be deployed at ORNL in 2026 under an innovative partnership with AMD, will expand DOE’s near-term AI capacity and accelerate progress on critical lighthouse problems identified in the Genesis Mission, including fusion, fission, materials, quantum, advanced manufacturing, and the grid.
The American Science Cloud (AmSC), a secure, connected and integrated, science-optimized environment will link DOE’s computing and experimental facilities. It will power a new era of discovery, linking powerful infrastructure with domain science to deliver solutions for national priorities.
ORNL is advancing a new model for research through autonomous, AI-driven laboratory environments. By connecting experimental systems with high-performance computing and cloud-based data platforms, researchers can run and refine experiments more quickly and efficiently. This approach creates a continuous loop between data, simulation, and experimentation, speeding progress across key scientific areas.
