Progress, and Applications
of the Human Genome Project
Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
Human Genome News, January-June 1997; 8:(3-4)
In its most recent update of May 1997, the Drosophila database FlyBase contains information about more than 46,000 alleles of some 14,000 genes. Many gene reports now link to reports about expression patterns and other features for associated proteins and transcripts. FlyBase presents descriptions of over 15,000 chromosomal aberrations as well as molecular maps and information about more than 1000 molecular constructs and 1000 transposons. The bibliography includes some 83,000 listings, many with links to associated genes and aberrations, and an address book lists over 5300 Drosophila researchers. Genotypes and ordering information for more than 13,000 Drosophila stocks are available.
Reports retrieved from gene searches have been enhanced by dividing alleles for each gene into "classical" and "in vitro" and references into "primary," "review," and "abstract." In its gene reports, FlyBase has extensive hyperlinks to other databases, most notably to sequence databank records, gene homologs from other organisms, and Medline citation records.
Inferences from automatically generated gene-location maps in the map directory are incorporated in individual gene reports and used for other map-based searches. Hardcopy versions of gene-order and annotated maps have been published as part of the FlyBase-edited Drosophila Information Service, volumes 78 and 79.
Flybase servers now provide access to the Interactive Fly, a database developed by Tom and Judy Brody (free-lance biologist and writer/editor). The Interactive Fly, which is designed to make Drosophila data more accessible to the nonspecialist, provides overviews of various Drosophila developmental and cellular processes integrated with information on vertebrate systems. The Interactive Fly is housed in the Allied Data section of FlyBase. Gene records are maintained with links to FlyBase, along with lists of genes participating in the described developmental and cellular processes.
FlyBase has developed a hierarchy of the Interactive Fly that links to specific pages, and gene lists link to individual gene records in both FlyBase and the Interactive Fly. Accessible in the FlyBase Allied Data and Genes directories, this hierarchy permits searches for genes grouped according to developmental and cellular pathways and functions.
Encyclopaedia of Drosophila
Some FlyBase data is merged with data from the Berkeley Drosophila Genome Project (BDGP) to form the Encyclopaedia of Drosophila, a collaboration between BDGP and FlyBase. [Version3.0 (BDGP server), http://shoofly.bdgp.berkeley.edu; Version 2.0 CD-ROM, email@example.com]
Supported by grants from NIH and the British Medical Research Council, FlyBase is a consortium of Drosophila biologists and computer scientists at Harvard University, Cambridge University (U.K.), and Indiana University, where the main FlyBase server is located. Several mirror sites are located around the world. To access Flybase:
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Human Genome Program, U.S. Department of Energy, Human Genome News (v8n3).
Last modified: Tuesday, January 13, 2004
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