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| This joint journal article index is a special feature of the Human Genome Project Information Web site in conjunction with the completion of the Human Genome Project (2003) and the publication of the working draft sequence (2001). |  |
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Human Genome Project Sequence Analysis Landmark Papers from Science and Nature |
The April 11, 2003 issue of Science and the April 24, 2003 issue of Nature (see also: special web focus) present a special collection of news, viewpoints, and other articles to celebrate the 50th anniversary of one of the signpost events of modern biology -- the publication of the structure of DNA -- and the new directions in molecular biology that the double-helix discovery has marked out in the subsequent half-century.
The Feb. 16, 2001, issue
of Science and Feb. 15, 2001, issue of Nature
contain the first analyses of the working draft human genome sequence. Nature
papers include initial sequence analyses generated by the publicly sponsored
Human Genome Project, while Science
publications focus on the draft sequence reported by the private company, Celera
Genomics.
Because of the importance
of these landmark papers, both Science and Nature have provided
free and unrestricted access to all articles. An index and links follow.
The Papers
| Quick Links to Papers
by Topic |
|
Introduction
Barbara R. Jasny and Leslie Roberts
Science Apr 11 2003: 277
| Full Text
| PDF |
The Human Genome
Project: Lessons from Large-Scale Biology
Francis S. Collins, Michael Morgan, Aristides Patrinos
Science Apr 11 2003: 286
| Summary
| Full Text
| PDF |
Realizing the Potential
of the Genome Revolution: The Genomes to Life Program
Marvin E. Frazier, Gary M. Johnson, David G. Thomassen, Carl E. Oliver, Aristides
Patrinos
Science Apr 11 2003: 290
| Summary
| Full Text
| PDF |
A Vision for the
Future of Genomics Research
Francis S. Collins, Eric D. Green, Alan E. Guttmacher, Mark S. Guyer
A blueprint for the genomic era.
Nature Apr 24 2003: 835
Full
text | PDF
(1072k)
Genetics and the
Making of Homo sapiens
Sean B. Carroll
Nature Apr 24 2003: 849
Summary
| Full
text | PDF
(310k)
Genome Sequencing:
Revelations from a Bread Mould
Jonathan Arnold, Nelson Hilton
Nature Apr 24 2003: 821
Full
text | PDF
(90k)
A physical
map of the human genome
The International Human Genome Mapping Consortium
Nature 409, 934-941 (15 February 2001)
| Summary
| Full
Text | PDF
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The
sequence of the human genome
The Celera Genomics Sequencing Team
Science Feb 16 2001: 1304-1351.
[Abstract]
[Full Text]
[Supplemental
Data]
The
physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X
D. R. Bentley, et al.
Nature 409, 942-943 (15 February 2001)
| First
Paragraph | Full
Text | PDF
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A
physical map of the human Y chromosome
Charles A. Tilford, et al.
Nature 409, 943-945 (15 February 2001)
| First
Paragraph | Full
Text | PDF
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A high-resolution
map of human chromosome 12
Kate T. Montgomery, et al.
Nature 409, 945-946 (15 February 2001)
| First
Paragraph | Full
Text | PDF
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A
physical map of human chromosome 14
Thomas Brüls,
et al.
Nature 409, 947-948 (15 February 2001)
| First
Paragraph | Full
Text | PDF
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Integration
of telomere sequences with the draft human genome sequence
H. C. Riethman, et al.
Nature 409, 948-951 (15 February 2001)
| First
Paragraph | Full
Text | PDF
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Comparison
of human genetic and sequence-based physical maps
Adong Yu, et al.
Nature 409, 951-953 (15 February 2001)
| First
Paragraph | Full
Text | PDF
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Integration
of cytogenetic landmarks into the draft sequence of the human genome
V. G. Cheung,
et al.
Nature 409, 953-958 (15 February 2001)
| First
Paragraph | Full
Text | PDF
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Mining
the draft human genome
Ewan Birney,
et al.
Nature 409, 827-828 (15 February 2001)
| Summary
| Full
Text | PDF
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Keeping
time with the human genome
Jonathan D. Clayton,
et al.
Nature 409, 829-831 (15 February 2001)
| Summary
| Full
Text | PDF
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Expressing
the human genome
Rossella Tupler,
et al.
Nature 409, 832-833 (15 February 2001)
| Summary
| Full
Text | PDF
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Functional
annotation of mouse genome sequences
Joseph
H. Nadeau,
et al.
Science Feb 16 2001: 1251-1255.
A
genomic perspective on membrane compartment organization
Jason B. Bock,
et al.
Nature 409, 839-841 (15 February 2001)
| Summary
| Full
Text | PDF
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Genomics,
the cytoskeleton and motility
Thomas D. Pollard
Nature 409, 842-843 (15 February 2001)
| Summary
| Full
Text | PDF
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Can
sequencing shed light on cell cycling?
Andrew W. Murray,
et al.
Nature 409, 844-846 (15 February 2001)
| Summary
| Full
Text | PDF
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Evolutionary
analyses of the human genome
Wen-hsiung Li,
et al.
Nature 409, 847-849 (15 February 2001)
| Summary
| Full
Text | PDF
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Experimental
annotation of the human genome using microarray technology
D. D. Shoemaker,
et al.
Nature 409, 922-927 (15 February 2001)
| Summary
| Full
Text | PDF
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Guide
to the draft human genome
Tyra G. Wolfsberg,
et al.
Nature 409, 824-826 (15 February 2001)
| Summary
| Full
Text | PDF
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What
if there are only 30,000 human genes?
Jean-Michel
Claverie
Science Feb 16 2001: 1255-1257.
[Summary]
[Full Text]
Making
sense of the sequence
David
J. Galas
Science Feb 16 2001: 1257-1260.
[Summary] [Full
Text]
Our
genome unveiled
David Baltimore
Nature 409, 814-816 (15 February 2001)
| Full
Text | PDF|
Genome
speak
Peer Bork,
et al.
Nature 409, 815 (15 February 2001)
| Full
Text | PDF
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The
maps: Clone by clone by clone
Maynard V. Olson
The public project's sequencing strategy involved producing a map of the human
genome and then pinning sequence to it. This helps to avoid errors in the sequence,
especially in repetitive regions.
Nature 409, 816-818 (15 February 2001)
| Full
Text | PDF
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The
draft sequences: Filling in the gaps
Peer Bork,
et al.
Nature 409, 818-820 (15 February 2001)
| Full
Text | PDF
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The
draft sequences: Comparing species
Gerald M. Rubin
Nature 409, 820-821 (15 February 2001)
| Full
Text | PDF
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Dissecting
human disease in the postgenomic era
Leena Peltonen and Victor A. McKusick
Science Feb 16 2001: 1224-1229.
[Summary] [Full
Text]
...to
a future of genetic medicine
Aravinda Chakravarti
Nature 409, 822-823 (15 February 2001)
| Full
Text | PDF
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A genomic
view of immunology
Aude M. Fahrer,
et al.
Nature 409, 836-838 (15 February 2001)
| Summary
| Full
Text | PDF
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Human
disease genes
Gerardo Jimenez-Sanchez,
et al.
Nature 409, 853-855 (15 February 2001)
| Summary
| Full
Text | PDF
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A map
of human genome sequence variation containing 1.42 million single nucleotide
polymorphisms
The International SNP Map Working Group
Nature 409, 928-933 (15 February 2001)
| Summary
| Full
Text | PDF
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Single
nucleotide polymorphisms: From the evolutionary past...
Mark Stoneking
Nature 409, 821-822 (15 February 2001)
| Full
Text | PDF
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Toward
behavioral genomics
Peter McGuffin,
et al.
Science Feb 16 2001: 1232-1249.
Learning
about addiction from the genome
Eric J. Nestler,
et al.
Nature 409, 834-835 (15 February 2001)
| Summary
| Full
Text | PDF
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Bioinformatics--Trying
to swim in a sea of data
David S. Roos
Science Feb 16 2001: 1260-1261.
Computational
comparison of two draft sequences of the human genome
John Aach,
et al.
Nature 409, 856-859 (15 February 2001)
| Summary
| Full
Text | PDF
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Are you ready
for the revolution?
Declan Butler
Nature 409, 758-760 (15 February 2001)
| Full
Text | PDF
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The human
genome and our view of ourselves
Svante
Pääbo
Science Feb 16 2001: 1219-1220.
[Summary]
[Full Text]
Political
issues in the genome era
James M. Jeffords and Tom Daschle
Science Feb 16 2001: 1249-1251.
[Summary] [Full
Text]
Proteomics
in genomeland
Stanley Fields
Science Feb 16 2001: 1221-1224.
[Summary] [Full
Text]
Watching
genes build a body
Gretchen Vogel
Science Feb 16 2001: 1181.
[Summary] [Full
Text]
What's
next for the genome centers?
Elizabeth
Pennisi
Science Feb 16 2001: 1204-1207.
[Summary] [Full
Text]
Hunting
for collaborators of killer toxins
Jocelyn
Kaiser
Science Feb 16 2001: 1207.
[Summary] [Full
Text]
The human
genome
Elizabeth Pennisi
Science Feb 16 2001: 1177-1180.
[Summary] [Full
Text]
Genomania
meets the bottom line
David Malakoff and Robert F. Service
Science Feb 16 2001: 1193-1203.
[Summary] [Full
Text]
Can data
banks tally profits?
Robert
F. Service
Science Feb 16 2001: 1203.
[Summary] [Full
Text]
Will a
smaller genome complicate the patent chase?
David Malakoff
Science Feb 16 2001: 1194.
[Summary]
[Full Text]
Controversial
from the start
Leslie
Roberts
Science Feb 16 2001: 1182-1188.
[Summary] [Full
Text]
A history
of the human genome project
Leslie
Roberts,
et al.
Science Feb 9 2001: 1195.
[Summary] [Full
Text]
In their
own words
Science
Feb 9 2001: 1196.
[Summary] [Full
Text]
What a long,
strange trip it's been
Nature 409, 756 - 757 (15 February 2001)
| Full
Text | PDF
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The
human genome
Editorial by Barbara R. Jasny and Donald Kennedy
Science Feb 16 2001: 1153.
[Summary]
Human genomes,
public and private
Editorial
Nature Feb 15 2001: 409
[Full
Text]
Molecular
structure of nucleic acids: A structure for deoxyribose nucleic acid
WATSON, J. D. & CRICK, F. H. C.
Nature 171, 737-734 (1953)
| Full Text
| PDF
|
Science
genome map
Science Feb 16 2001: 1218.
[Summary] [Full
Text]
Funny genes
/ The DNA vault / Genome hubs / Genomes for all
Science Feb 16 2001: 1163
[Full Text]
For more information on these topics on the Human Genome Project Information website, see
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