Invention Reference Number
Researchers and industry laboratories often face challenges delivering controlled low-dose radiation exposures while maintaining standard biological growth conditions. This technology provides an irradiation source plate designed for high-throughput testing within a standard 96-well plate environment. The platform enables simultaneous evaluation of multiple radiation conditions while maintaining controlled temperature, humidity, and CO2 levels. By supporting well-characterized and reproducible dose delivery dose delivery within conventional laboratory growth chambers, the technology expands access to advanced radiation exposure studies without requiring specialized irradiation infrastructure.
Description
ORNL has developed a compact irradiation source plate that enables controlled low-dose and low-dose-rate radiation exposure studies for biological and materials research applications. The technology is designed for use with standard 96-well culture plates and supports high-throughput experimentation across multiple test conditions simultaneously.
The system incorporates a specialized source geometry that delivers consistent radiation exposure to individual wells while operating within conventional laboratory incubators and growth chambers. The source geometry is configured to provide different dose rates to different wells within the same plate, allowing multiple exposure conditions, controls, and replicate samples to be irradiated simultaneously under identical environmental conditions. This approach allows researchers to maintain standard environmental conditions during irradiation experiments, improving experimental flexibility and reducing dependence on large or complex irradiation systems.
The close placement of the source plate to the culture plate reduces the amount of radioactive material required to achieve target dose rates while supporting accurate dose characterization. The platform may be adapted for use in biological research, pharmaceutical testing, regulatory studies, and selected materials testing applications.
Benefits
- Enables high-throughput low-dose and low-dose-rate radiation studies
- Maintains standard laboratory environmental conditions during testing
- Supports simultaneous evaluation of multiple dose-rate conditions, controls, and replicate samples.
- Reduces dependence on specialized irradiation equipment
- Improves accessibility for a wider range of research laboratories
Applications and Industries
- Pharmaceutical research, radioprotective screening, and radiosensitizer testing
- Biomedical, cellular, DNA damage, and radiation biology research laboratories
- Regulatory, toxicology and environmental exposure studies
- Materials testing and evaluation
- Academic, government and industry research institutions
Contact
To learn more about this technology, email partnerships@ornl.gov or call 865-574-1051.
