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Technology

BESC - Transcriptional Regulator of Phosphoenolpyruvate Shunt between Shikimate and Glycolysis Pathways

Invention Reference Number

201603647

Technology Summary

The transcriptional repressor functions as a modulator of PEP fate by repressing the shikimate pathway via transcriptional regulation. We also demonstrated that this transcriptional regulation forms the basis of the SA-JA/ET antagonism which plays a major role in the tradeoff between growth and immune responses in plants. Further, our results suggest that components of transcriptional regulation related to the glycolysis pathway post pyruvate biosynthesis are conserved between plants and humans and can regulate genes involved human/animal cancer development.

Inventors

Anthony C Bryan
Biosciences Division
Gerald Tuskan
Biosciences Division
Jin-Gui Chen
Biosciences Division
Meng Xie
Biosciences Division
Wellington Muchero
Biosciences Division

Licensing Contact

JENNIFER T CALDWELL
caldwelljt@ornl.gov
(865) 574-4180