Michael L Simpson

Michael L Simpson

Corporate Fellow, Group Leader Nanofabrication Research Lab Center for Nanophase Materials Sciences, Director Joint Institute for Biological Sciences

Bio

Dr. Michael L. Simpson received his Ph.D. in Electrical Engineering from the University of Tennessee, Knoxville in 1991. He started his research life as an Electrical Engineer, but followed the call of interdisciplinary research to the boundaries between life, computational, and physical sciences. His research has made important contributions to the use of nanotechnology to enable the transfer of information across the biological-synthetic device boundary and the development of a fundamental understanding of Noise Biology. Simpson has published more than 150 refereed journal papers that have been cited more than 8,500 times, has been awarded 35 patents, and has presented numerous invited talks. His work has been internationally recognized as he is a Fellow of AAAS, the IEEE, and the AIMBE, a Battelle Memorial Institute Distinguished Inventor, was named the UT-Battelle Distinguished Scientist of the year for 2009, and became an ORNL Corporate Fellow in 2014. He won the Kermit Fischer Environmental Award and was a finalist for a Discover Magazine Technology Innovation award in 1998, and he serves on the editorial boards of the Journal of Nanomedicine and Biotherapeutic Discovery and the International Journal of Natural Computing Research. Currently Simpson is the Group Leader of the Nanofabrication Research Laboratory in the Center for Nanophase Materials Sciences at ORNL, a Professor in the Departments of Material Science and Engineering and Energy Science and Engineering, the Director of the UT/ORNL Joint Institute for Biological Sciences, and the Assistant Director of the Bredesen Center for Interdisciplinary Research and Graduate Education.

Awards

• Elected Fellow of The American Association for the Advancement of Science (AAAS), November 2011.

• Inducted into the College of Fellows of the American Institute for Medical and Biomedical Engineering, ‘For contributions to the understanding and engineering of information transport in genetic circuits and systems’, February 2010.

• Received UT-Battelle Distinguished Scientist Award for 2009 for ‘Pioneering efforts to establish the research field of Noise Biology.’

• Named a Fellow of the IEEE for ‘Contributions to nanotechnology in engineered devices and biology’, January 1, 2008.

• Named a Battelle Memorial Institute Distinguished Inventor in 2007

• 1998 Kermit Fischer Environmental Award for the Pioneering Development of an Integrated CMOS Photo-Spectrometer for Wide Applications including Environmental Monitoring.

• Finalist for a 1998 Discover Magazine Technology Innovation award for the development of the Bioluminescent Bioreporter Integrated Circuit.

• Awarded Lockheed-Martin Energy Research Corporation Medal for Excellence in Technical Achievement, May 1998 for the co-development of a deep submicron lithography method.

• Awarded Lockheed-Martin Energy Research Corporation Medal for Excellence in Technical Achievement, May 1998 for the co-development of an integrated circuit for a collider detector application.

• Awarded Lockheed-Martin Energy Research Corporation Medal for Excellence in Technical Achievement, May 1997 for the development of a single-chip photo-spectrometer.

Publications

Publications
~8,900 total cites; h-index=52; Google scholar profile:
http://scholar.google.com/citations?user=VQWzQg0AAAAJ

Most Cited Publications (**** 500 or more cites; *** 200 or more cites; ** 100 or more cites, * 50 or more cites)

1. **** Melechko, A.V., V.I. Merkulov, T.E. McKnight, M.A. Guillorn, K.L. Klein, D.H. Lowndes, and M.L. Simpson. “Vertically aligned carbon nanofibers and related structures: Controlled synthesis and directed assembly.” J. Appl. Phy., 97(4), Feb. 15, 2005, 041301-39.
2. ****Adcox, K., et al. "PHENIX detector overview," Nuclear Instruments & Methods in Physics Research Section a- Accelerators Spectrometers Detectors and Associated Equipment, vol. 499, pp. 469-479, 2003.
3. *** Merkulov, V. I., A. V. Melechko, M. A. Guillorn, D. H. Lowndes, and M. L. Simpson. “Alignment mechanism of carbon nanofibers produced by plasma-enhanced chemical-vapor deposition”. Appl. Phys. Lett., 79(18), October 29, 2001, 2970-2972.
4. *** Austin, D. W., M. S. Allen, J. M. McCollum, R. D. Dar, J. R. Wilgus, G. S. Sayler, N. F. Samatova, C. D. Cox, & M. L. Simpson, “Gene Network Shaping of Inherent Noise Spectra”, Nature 439, Feb. 2, 2006, 608-611
5. *** Merkulov, V. I. , M. A. Guillorn, D. H. Lowndes, M. L. Simpson, E. Voelkl, “Shaping carbon nanostructures by controlling the synthesis process”, Appl. Phys. Lett., 79(8), August 20, 2001, 1178-1180..
6. *** Aphecetche, L., et al. "PHENIX calorimeter," Nuclear Instruments & Methods in Physics Research Section a- Accelerators Spectrometers Detectors and Associated Equipment, vol. 499, pp. 521-536, 2003.
7. ** Allen, M., et al. "PHENIX inner detectors," Nuclear Instruments & Methods in Physics Research Section a- Accelerators Spectrometers Detectors and Associated Equipment, vol. 499, pp. 549-559, 2003.
8. ** Simpson, M. L., C. D. Cox, G. S. Sayler. “Frequency Domain Analysis of Noise in Autoregulated Gene Circuits”. Proc. Nat. Acad. Sci. USA 100, April 15, 2003, 4551-4556.
9. ** McKnight, T. E., A. V. Melechko, D. K. Hensley, G. D. Griffin, M. A. Guillorn, V. I. Merkulov, F. Serna, M. J. Doktycz, D. H. Lowndes, and M. L. Simpson. “Intracellular Integration of Synthetic Nanostructures with Viable Cells for Non-Inheritable Genetic Modification”. Nanotechnology 14, May 2003, 551-556.
10. ** McCollum, J. M., G. D. Peterson, C. D. Cox, M. L. Simpson, & N. F. Samatova, “The sorting direct method for stochastic simulation of biochemical systems with varying reaction execution behavior”, Comp. Bio. and Chem. 30, Feb. 2006, 39-49.
11. ** Guillorn, M. A., T. E. McKnight, A. Melechko, V. I. Merkulov, D. W. Austin, D. H. Lowndes and M. L. Simpson. “Individually addressable vertically aligned carbon nanofiber-based electrochemical probes”. J. Appl. Phys. 91(6), March 15, 2002, 3824-3828.
12. ** Simpson, Michael L., Gary S. Sayler, Steven Ripp, David E. Nivens, Bruce M. Applegate, Michael J. Paulus, and Gerald E. Jellison Jr. "Bioluminescent-Bioreporter Integrated Circuits Form Novel Whole-Cell Biosensors". Trends Biotech., Vol. 16, August 1998, pp. 332-338.
13. ** Merkulov, V. I., A. V. Melechko, M. A. Guillorn, D. H. Lowndes, M. L. Simpson, J. H. Whealton, R. J. Raridon. “Controlled alignment of carbon nanofibers in a large-scale synthesis process”. Appl. Phys. Lett. 80(25), June 24, 2002, 4816-4818.
14. ** McKnight, T. E., A. V. Melechko, G. D. Griffin, M. A. Guillorn, V. I. Merkulov, F. Serna, D. K. Hensley, M. J. Doktycz, D. H. Lowndes, and M. L. Simpson. “Tracking Gene Expression after DNA Delivery Using Spatially Indexed Nanofiber Arrays.” Nano Letts. 4(7); July 7, 2004, 1213-1219.
15. ** Weinberger, L. S., R. D. Dar, M. L. Simpson (2008) “Transient-mediated fate determination in a transcriptional circuit of HIV” Nature Genetics, 40(4), 466-470.
16. ** Guillorn, M. A., E.. D. Ellis, C. L. Britton, M. L. Simpson, A.V. Melechko, V.I. Merkulov , G.J. Bordonaro, D. Woodie, L.R. Baylor, and D. H. lowndes. “Operation of a gated field emitter using an individual carbon nanofiber cathode”. Appl. Phys. Lett., 79(21), November 19, 2001, 3506-3508.
17. ** Simpson, M. L., G. S. Sayler, J. T. Fleming, and B. A. Applegate. “Whole-cell biocomputing: engineering the information processing functionality of cells”. Trends in Biotechnology 19(8), August 2001, 317-323.
18. ** Nivens, D. E., T. E. McKnight, S. A. Moser, S. J. Osbourn, M. L. Simpson, and G. S. Sayler, "Bioluminescent bioreporter integrated circuits: potentially small, rugged and inexpensive whole-cell biosensors for remote environmental monitoring," J. Appl. Microbio., vol. 96, pp. 33-46, 2004.
19. ** Yu, Z., T. E. McKnight, M. N. Ericson, A. V. Melechko, M. L. Simpson, B. Morrison III (2007) Vertically aligned carbon nanofiber arrays record hippocampal slice electrophysiological signals, Nano Letts. 7(8), 2188 – 2195.
20. ** Morrison, D. P. et al. The PHENIX experiment at RHIC. Nuclear Physics A 638, 565c-569c (1998).

Patents

1. T. E. McKnight, A. V. Melechko, G. D. Griffin, M. A. Guillorn, V. I. Merkulov, and M. L. Simpson. Patent Number. 8,993,327 “Parallel Macromolecular Delivery and Biochemical/Electrochemical Interface to Cells Employing Nanostructures”.

2. T. E. McKnight, A. V. Melechko, and M. L. Simpson. Patent Number 8,343,766 “Method and Apparatus for Sustaining Viability of Biological Cells on a Substrate”.

3. A. V. Melechko, T. E. McKnight, M. A. Guillorn, B. Illic, V. I. Merkulov, M. J. Doktycz, D. H. Lowndes, and M. L. Simpson. Patent Number 8,142,877 “Nano transfer and nanoreplication using deterministically grown sacrificial nanotemplates”.

4. T. E. McKnight, A. V. Melechko, and M. L. Simpson. Patent Number 8,101,388 “Method and structure for extracting molecular species”.

5. T. E. McKnight, A. V. Melechko, and M. L. Simpson. Patent Number 8,076,124 “Method and apparatus for sustaining viability of biological cells on a substrate”.

6. A. V. Melechko, T. E. McKnight, M. A. Guillorn, B. Illic, V. I. Merkulov, M. J. Doktycz, D. H. Lowndes, and M. L. Simpson. Patent Number 8,003,220 “Nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates”.

7. V. I. Merkulov, A. V. Melechko, M. A. Guillorn, D. H. Lowndes, and M. L. Simpson. Patent Number 7,947,976 “Controlled Alignment of Catalytically Grown Nanostructures in a Large-Scale Synthesis Process”.

8. A. V. Melechko, T. E. McKnight, M. A. Guillorn, B. Ilic, V. I. Merkulov, M. J. Doktycz, D. H. Lowndes, and M. L. Simpson. Patent Number 7,943,196 “Nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates”.

9. M. J. Doktycz, M. L. Simpson, T. E. McKnight, A. V. Melechko, D. H. Lowndes, M. A. Guillorn, V. I. Merkulov. Patent Number 7,641,863 “Nanoengineered membranes for controlled transport”.

10. V. I. Merkulov, A. V. Melechko, M. A. Guillorn, D. H. Lowndes, M. L. Simpson. Patent Number 7,408,186 “Controlled Alignment Catalytically Grown Nanostructures”.

11. M. L. Simpson, M. J. Paulus, G. S. Sayler, B. M. Applegate, S. A. Ripp. Patent Number 7,371,538 “Microluminometer chip and method to measure bioluminescence”.

12. V. I. Merkulov, A. V. Melechko, M. A. Guillorn, D. H. Lowndes, M. L. Simpson. Patent Number 7,245,068 “Apparatus for controlled alignment of catalytically grown nanostructures”.

13. A. V. Melechko, T. E. McKnight, M. A. Guillorn, B. Ilic, V. I. Merkulov, M. J. Doktycz, D. H. Lowndes, and M. L. Simpson. Patent Number 7,229,692 “Nanoconduits and nanoreplicants”.

14. M. L. Simpson, M. J. Paulus, G. S. Sayler, B. M. Applegate, S. A. Ripp. Patent Number 7,208,286 “Bioluminescent bioreporter integrated circuit devices and methods for detecting ammonia”.

15. M. A. Guillorn, B. Ilic, A. V. Melechko, V. I. Merkulov, D. H. Lowndes, M. L. Simpson. Patent Number 7,151,256 “Vertically aligned nanostructure scanning probe microscope tips”.

16. M. A. Guillorn, T. E. McKnight, V. I. Merkulov, A. V. Melechko, M. L. Simpson. Patent Number 7,144,287 “Individually electrically addressable carbon nanofibers on insulating substrates”.

17. V. I. Merkulov, D. H. Lowndes, M. A. Guillorn, M. L. Simpson. Patent Number 7,109,515 “Carbon containing tips with cylindrically symmetrical carbon containing expanded bases”.

18. M. L. Simpson, M. J. Paulus, G. S. Sayler, B. Applegate, S. Ripp. Patent Number 7,090,992 “Bioluminescent bioreporter integrated circuit devices and methods for detecting estrogen”.

19. G. S. Sayler, J. T. Fleming, B. Applegate, M. L. Simpson. Patent Number 7,020,560. “Methods for cell-based combinatorial logic”.

20. M. A. Guillorn, T. E. McKnight, V. I. Merkulov, A. V. Melechko, M. L. Simpson. Patent Number 6,982,519. “Individually electrically addressable vertically aligned carbon nanofibers on insulating substrates”.

21. V. I. Merkulov, A. V. Melechko, M. A. Guillorn, D. H. Lowndes, M. L. Simpson. Patent Number 6,958,572. “Controlled non-normal alignment of catalytically grown nanostructures in a large-scale synthesis process”.

22. C. E. Thomas, L. R. Baylor, E. Voelkl, M. L. Simpson, M. J. Paulus, D. H. Lowndes, J. Whealton, J. C. Whitson, J. B. Wilgen. Patent Number 6,917,043. “Individually addressable cathodes with integrated focusing stack or detectors”.

23. M. L. Simpson, M. J. Paulus, G. S. Sayler, B. M. Applegate, S. A. Ripp. Patent Number 6,905,834. “Bioluminescent bioreporter integrated circuit detection methods”.

24. M. A. Guillorn, M. L. Simpson, V. I. Merkulov, A. V. Melechko, D. H. Lowndes. Patent Number 6,858,455. “Gated fabrication of nanostructure field emission cathode material within a device”.

25. M. L. Simpson, D. H. Lowndes, V. I. Merkulov, M. A. Guillorn, and C. L. Britton. Patent Number 6,692,324. "Single Self-Aligned Carbon Containing Tips".

26. G. S. Sayler, M. L. Simpson, B. M. Applegate, S. A. Ripp. Patent Number 6,673,596. “In Vivo Biosensor Apparatus and Method of Use”.

27. V. I. Merkulov, D. H. Lowndes, M. A. Guillorn, M. L. Simpson. Patent number 6,649,431. "Carbon tips with expanded bases grown with simultaneous application of carbon source and etchant gases ".

28. M. J. Paulus, Michael J. H. Sari-Sarraf, M. L. Simpson, and C. L. Britton, Jr. Patent Number 6,399,951 “Simultaneous CT and SPECT tomography using CZT detectors”.

29. C. E. Thomas, L. R. Baylor, E. Voelkl, M. L. Simpson, M. J. Paulus, D. H. Lowndes, J. H. Whealton, J. C. Whitson, J. B. Wilgen. Patent Number 6,498,349. “Electrostatically focused addressable field emission array chips (AFEA's) for high-speed massively parallel maskless digital E-beam direct write lithography and scanning electron microscopy”.

30. M. L. Simpson, G. S. Sayler, and M. J. Paulus. Patent Number 6,117,643 “Bioluminescent Bioreporter Integrated Circuit”.

31. M. L. Simpson, M. N. Ericson, G. E. Jellison, A. L. Wintenberg, W. B. Dress, and D. N. Sitter. Patent Number 5,965,873 , “Photo-Spectrometers, Method of Use and Manufacture”.

32. Larry R. Baylor, Clarence E. Thomas, Edgar Voelkl, James A. Moore, Michael L. Simpson, and Michael J. Paulus. Patent Number 5,892,231, “Virtual mask digital electron beam lithography”.

33. M. L. Simpson and T. W. Raudorf. Patent Number 4,937,452, “Charge Trapping Correction in Photon Detection Systems”.

34. M. L. Simpson. Patent Number 4,878,014, “Ion Beam Profile Scanner having Symmetric Detector Surface to Minimize Capacitance Noise”.

35. M. L. Simpson. Patent Number 4,833,394, “Ion Beam Profile Analyzer with Noise Compensation”.

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