Amber A McBride

Staff Scientist

Amber McBride is a Staff Scientist in the Biosciences division at Oak Ridge National Laboratory. Dr. McBride is a molecular biologist broadly interested in nanotechnology, drug delivery, and disease. Specifically, she is researching the epigenetic effects of clinically relevant doses of alpha radiation in cancer. Her research spans scales from the molecule to the ecosystem level, taking advantage of CRISPR-Cas9 editing to ensure safe, secure and resilient outcomes to gene editing approaches. Dr. McBride received her Ph.D. in Nanoscience & Microsystems Engineering in 2014 at the University of New Mexico in Albuquerque. As a graduate student, she was a National Science Foundation Integrative Graduate Education and Research (IGERT) Integrating Nanotechnology with Cell Biology and Neuroscience Graduate Fellow and a National Cancer Institute New Mexico Cancer Nanotech Training Center Graduate Fellow. She also conducted research as an International Research Scholar at the Technical University of Munich in Munich, Germany. After completing her Ph.D., she expanded her focus to work in CRISPR-Cas genome editing in mammalian hosts as a Postdoctoral Research Associate at Sandia National Laboratories in Albuquerque, New Mexico. In 2018, she received a staff appointment and Early Career Laboratory Directed Research and Development (LDRD) funding for her research at ORNL.

Selected publications:

Sava-Gallis DF, Butler KS, Agola JO, Pearce CJ. and McBride AA. Antibacterial Countermeasures via MOF−supported sustained therapeutic release. 2019. ACS Applied Materials & Interfaces.

Sava-Gallis DF, Butler KS, Rohwer LE, McBride AA, Vincent G, Chong CV, Pearce CJ and Luk TS. 2018. Biocompatible MOFs with high absolute quantum yield for bioimaging in the second near infrared window. CrystEngComm. pp.5919-5924.

McBride AA, Price DN, and Muttil P. Pulmonary delivery of magnetically targeted nano-in-microparticles. Cancer Nanotechnology: Methods and Protocols. 2017. pp. 369-378.

McBride AA, Price DN, and Muttil P. Preparation and Characterization of Magnetic Nano-in-Microparticles for Pulmonary Delivery. Cancer Nanotechnology: Methods and Protocols. 2017. pp. 99-108.

Price DN*, McBride AA*, Anton M, Kusewitt DF, Norenberg JP, MacKenzie DA, Thompson TA, and Muttil P. Longitudinal Assessment of Lung Cancer Progression in Mice Using the Sodium Iodide Symporter Reporter Gene and SPECT/CT Imaging. PloS one 11.12. 2016.: e0169107. *Authors contributed equally to first authorship.

Price, Dominique N., Nitesh K. Kunda, McBride, Amber A., and Pavan Muttil. "Vaccine Preparation: Past, Present, and Future." Delivery Systems for Tuberculosis Prevention and Treatment (2016): 69.

Price DN, Kusewitt DF, Lino CA, McBride AA, and Muttil P. Oral tolerance to environmental mycobacteria interferes with intradermal but not pulmonary, immunization against tuberculosis." PLoS Pathog 12, no. 5. 2016. pp e1005614.

McBride AA, Price DN, Lamoureux DR, Elmaoued AA, Vargas JM, Adolphi NA, and Muttil P. Preparation and characterization of novel magnetic nano-in-microparticles for site-specific pulmonary drug delivery. Molecular Pharmaceutics 10.10. 2013. pp. 3574-3581.

McBride AA and Muttil P. A Pilot Study Targeting Nano-in-Microparticles (NIMs) in Rat Lungs Ex Vivo. Respiratory Drug Delivery. 2013. pp. 423-428.

McBride AA, Lamoureux LR, Price DN and Muttil P. Novel Preparation and Characterization of Magnetic Nano-in-Microparticle Dry Powders for Directed Drug Delivery: An Application to Lung Cancer. Respiratory Drug Delivery. no.3. 2012. pp. 815-820.

Kuethe, DO, McBride A, and Altobelli S. Velocity of mist droplets and suspending gas imaged separately." Journal of Magnetic Resonance 216. 2012. pp. 88-93.

Palikij J, Ebert D, Preston M, McBride AA, and Jander R. Evidence of the honeybee’s place knowledge in the vicinity of the hive. Journal of insect physiology. 58 (10). 2012. pp. 1289-1298.

Muttil P, Price DN, McBride, AA. Pulmonary immunization for TB with live cell-based vaccines: the importance of the delivery route. Therapeutic Delivery Vol. 2, No. 12. 2011. 1519-1522.

Vargas JM, McBride AA, Plumley JB, Fichou Y, Memon TA, Shah B, Cook NC, Akins BA, Rivera AC, Genady AS, O’Brien JR, Adolphi NL, Smyth DC and Osiski M. Synthesis and characterization of core/shell Fe3O4/ZnSe fluorescent magnetic nanoparticles