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Frontier supercomputer

A multi-institutional team, led by a group of investigators at Oak Ridge National Laboratory, has been studying various SARS-CoV-2 protein targets, including the virus’s main protease. The feat has earned the team a finalist nomination for the Association of Computing Machinery, or ACM, Gordon Bell Special Prize for High Performance Computing-Based COVID-19 Research.

coronavirus

NellOne Therapeutics has licensed a drug delivery system from the Department of Energy’s Oak Ridge National Laboratory that is designed to transport therapeutics directly to cells infected by SARS-CoV-2, the virus causing COVID-19.

Sandra Davern performs cell based assays to evaluate cell death and DNA damage in response to radiation in order to gain a better understanding of how radioisotope nanoparticles affect the human body.

When Sandra Davern looks to the future, she sees individualized isotopes sent into the body with a specific target: cancer cells.

U.S. Department of Energy Deputy Secretary Mark Menezes (right) tours the DemeTECH N95 filter material production area with Xin Sun, ORNL interim associate laboratory director (center) and Craig Blue, ORNL advanced manufacturing program manager. Credit: US Dept. of Energy

A collaboration between the ORNL and a Florida-based medical device manufacturer has led to the addition of 500 jobs in the Miami area to support the mass production of N95 respirator masks.

Jianlin Li employs ORNL’s world-class battery research facility to validate the innovative safety technology. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Soteria Battery Innovation Group has exclusively licensed and optioned a technology developed by Oak Ridge National Laboratory designed to eliminate thermal runaway in lithium ion batteries due to mechanical damage.

Xunxiang Hu, a Eugene P. Wigner Fellow in ORNL’s Materials Science and Technology Division, designed this machine to produce large, crack-free pieces of yttrium hydride to be used as a moderator in the core of ORNL’s Transformational Challenge Reactor and other microreactors. Credit: Xunxiang Hu/ORNL, U.S. Dept. of Energy

About 60 years ago, scientists discovered that a certain rare earth metal-hydrogen mixture, yttrium, could be the ideal moderator to go inside small, gas-cooled nuclear reactors.

Enzyme activity during organophosphate poisoning

Pick your poison. It can be deadly for good reasons such as protecting crops from harmful insects or fighting parasite infection as medicine — or for evil as a weapon for bioterrorism. Or, in extremely diluted amounts, it can be used to enhance beauty.

Joe Hagerman is expanding connected neighborhood research at ORNL and envisions buildings of the future as resources capable of managing the flow and exchange of energy based on economic and market signals – a concept known as transactive energy. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Department of Energy

Joe Hagerman, ORNL research lead for buildings integration and controls, understands the impact building technology innovations can have during times of crisis. Over a decade ago, he found himself in the middle of one of the most devastating natural disasters of the century, Hurricane Katrina.

Battery materials at interface

Scientists seeking ways to improve a battery’s ability to hold a charge longer, using advanced materials that are safe, stable and efficient, have determined that the materials themselves are only part of the solution.

The CrossVis application includes a parallel coordinates plot (left), a tiled image view (right) and other interactive data views. Credit: Chad Steed/Oak Ridge National Laboratory, U.S. Dept. of Energy

From materials science and earth system modeling to quantum information science and cybersecurity, experts in many fields run simulations and conduct experiments to collect the abundance of data necessary for scientific progress.