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Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL

OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.

Neutron scattering allowed direct observation of how aurein induces lateral segregation in the bacteria membranes, which creates instability in the membrane structure. This instability causes the membranes to fail, making harmful bacteria less effective.

As the rise of antibiotic-resistant bacteria known as superbugs threatens public health, Oak Ridge National Laboratory’s Shuo Qian and Veerendra Sharma from the Bhaba Atomic Research Centre in India are using neutron scattering to study how an antibacterial peptide interacts with and fights harmful bacteria.

ORNL nuclear engineer Chris Petrie

Oak Ridge National Laboratory is using ultrasonic additive manufacturing to embed highly accurate fiber optic sensors in heat- and radiation-resistant materials, allowing for real-time monitoring that could lead to greater insights and safer reactors.

(From left) ORNL Associate Laboratory Director for Computing and Computational Sciences Jeff Nichols; ORNL Health Data Sciences Institute Director Gina Tourassi; DOE Deputy Under Secretary for Science Thomas Cubbage; ORNL Task Lead for Biostatistics Blair Christian; and ORNL Research Scientist Ioana Danciu were invited to the White House to showcase an ORNL-developed digital tool aimed at better matching cancer patients with clinical trials.

OAK RIDGE, Tenn., March 4, 2019—A team of researchers from the Department of Energy’s Oak Ridge National Laboratory Health Data Sciences Institute have harnessed the power of artificial intelligence to better match cancer patients with clinical trials.

As part of a preliminary study, ORNL scientists used critical location data collected from Twitter to map the location of certain power outages across the United States.

Gleaning valuable data from social platforms such as Twitter—particularly to map out critical location information during emergencies— has become more effective and efficient thanks to Oak Ridge National Laboratory.

An ORNL-developed graphite foam, which could be used in plasma-facing components in fusion reactors, performed well during testing at the Wendlestein 7-X stellarator in Germany.

Scientists have tested a novel heat-shielding graphite foam, originally created at Oak Ridge National Laboratory, at Germany’s Wendelstein 7-X stellarator with promising results for use in plasma-facing components of fusion reactors.

The EPB Control Center monitors the company’s assets such as substations and buildings.

OAK RIDGE, Tenn., Feb. 12, 2019—A team of researchers from the Department of Energy’s Oak Ridge and Los Alamos National Laboratories has partnered with EPB, a Chattanooga utility and telecommunications company, to demonstrate the effectiveness of metro-scale quantum key distribution (QKD).

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While studying the genes in poplar trees that control callus formation, scientists at Oak Ridge National Laboratory have uncovered genetic networks at the root of tumor formation in several human cancers.

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OAK RIDGE, Tenn., Jan. 31, 2019—A new electron microscopy technique that detects the subtle changes in the weight of proteins at the nanoscale—while keeping the sample intact—could open a new pathway for deeper, more comprehensive studies of the basic building blocks of life. 

Nuclear—Deep space travel

By automating the production of neptunium oxide-aluminum pellets, Oak Ridge National Laboratory scientists have eliminated a key bottleneck when producing plutonium-238 used by NASA to fuel deep space exploration.