Table of Contents
Virtual Human Project - Standard Languages for Anatomical and Physiological Modeling
ORNL conducts basic and applied R&D in support of national & international goals
Outline
Motivations for new approach to human modeling
Apply tools of information technology to modeling human biology over wide scale
Virtual Human: an internal research program at ORNL
ORNL takes lead in early Virtual Human effort
Forum established for Digital Human effort
Conferences held to define the Digital Human
Synergy with other comprehensive, integrated human modeling efforts
Workshops/Conferences identified the need to adopt standards for interoperability
What is XML?
XML descriptions becoming common
physioML: An XML for physiological modeling
physioML flexible enough to describe quite different models and interfaces
Example 1: Cardiovascular circuit model
Example 2: Lung fluid transport model
Example 3: Hg-vapor inhalation model
What is an ontology?
How does it differ from XML?
Ontologies may be expressed using RDF (expression of semantics) & XML (syntax)
Ontologies are used in genome and cellular modeling
Digital Human: create anatomical ontology
Visualization tools needed to create anatomical models
Segmentation of CT images
PPT Slide
Future of web-delivered anatomical models
Visible Human in the CAVE
Realistic rendering of heart
To build Virtual Human will require a problem-solving environment
NetSolve developed to access clusters of HPC machines (Grid)
A prototype computational environment for complex 3D flow modeling
PPT Slide
PICMSS Java user interface
Model equations entered using Equation Formulator
PICMSS used to simulate pulmonary function
Common Component Architecture (CCA)
PPT Slide
Conclusion: adopt standard data schemas for anatomical and physiological modeling
Adopting schemas for data and model description will bridge the scales in human modeling
Acknowledgments
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Author: Richard C. Ward
Email: wardrc1@ornl.gov
Home Page: http://www.ornl.gov/virtualhuman
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