Nanoscale Molecular Cartography: Conbined Optical Spectroscopy and Mass Spectrometry for Multimodal Imaging of InterfacesMarch 01, 2013
Multidimensional Data Understanding - Chemical structure and processes require the ability to perform multidimensional analysis and use that knowledge to control processes and create structures on demand.
There exists a clear need to extend the limits of our understanding of chemical and physical phenomena of materials and biosystems at the nanoscale. Currently available techniques usually face a trade-off between spatial resolution and chemical information. The goal of atmospheric pressure chemical imaging at the nanometer scale with mass spectrometry has been until now approached by our group using near field effect laser desorption and proximal probe thermal desorption for surface sampling followed by a secondary ionization process like electrospray. Each of these sampling approaches can be coupled with an atomic force microscope (AFM) platform to give a multimoldal, physical and chemical imaging platform. The thermal desorption approach allows for the easy scaling of the technique all the way from the millimeter to the nanometer regime. In the nanometer regime, an AFM platform with silicon based heating AFM probes is used to locally desorb material from a surface with ~250 nanometer spatial resolution. The latest results from our group in these two areas will be presented. The future of all these techniques and the potential of high resolution chemical imaging via mass spectrometry using other sampling approaches combined with AFM will be discussed.