Mutation Research Genomics Initiative

Initiative Progress and Future Plans
 

Introduction  Interviews with Experts  Meetings Held or Planned

Initiative Presentation  ICPEMC Committee Report  Summary of Progress

1997 Developments

• Mutation Research Journal Adds New Genomics Section in 1997
• Genomics and Toxicology Symposium at Society of Toxicology Meeting
• NIEHS Promotes Environmental Genome Project

• BioMedNet Discussion Group on Mutation Detection
• Emerging Technologies
• AFM Imaging of DNA-Bound Proteins by Mitchel J. Doktycz
• Mutation Databases by R.G.H. Cotton
• Padlock Probes Detect Single Base Changes
• Genome Resources (Human and Model Organisms)
• Links to Related Web Sites (provided by the Virtual Library on Genetics)

• Response Form

The most direct way of assessing whether or not mutation has occurred at a particular point in the genome would be, by definition, to look at the DNA itself. Modern sophistications of DNA sequencing methods and recombinant DNA technology suggest that this will be the favoured method of the immediate future. Indeed, mutant forms of genes determining proteins for which there are gene-specific probes have already been detected using these approaches. The identification of particular regions of the genome is, however, still heavily dependent on the existence of a suitable DNA probe and this feature limits the application of this study at the present state of the art.

Yvonne H. Edwards and Susan Povey, "The Detection of Mutation by Electrophoresis in Man and Other Animals." Progress in Environmental Mutagenesis, Elsevier/North Holland Biomedical Press, M. Alacevic, Ed., 1980.

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This site was developed and implemented by J. S. Wassom, S. Milanez, C. D. Cochran, and S. Martin, Oak Ridge National Laboratory, Oak Ridge, TN 37830

Monday, July 16, 2007

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