The Mouse Gene Expression Database (GXD)

Martin Ringwald
The Jackson Laboratory
600 Main Street
Bar Harbor, ME 04609
USA
telephone: +1 (207) 288-6436
fax: +1 (207) 288-6132
email: ringwald@informatics.jax.org
prestype: Platform
presenter: Martin Ringwald

D.A. Begley, I.J. McCright, T.F. Hayamizu, D.P. Hill, C.M. Smith, J.A. Blake, J.T. Eppig, J.A. Kadin, J.E. Richardson, and M. Ringwald.
The Jackson Laboratory, Bar Harbor, ME 04069, USA

The Gene Expression Database (GXD) is a community resource of gene expression information for the laboratory mouse. By integrating many different types of expression data, GXD provides increasingly complete information about what transcripts and proteins are produced by what genes; where, when and in what amounts these gene products are expressed; and how their expression varies in different mouse strains and mutants. Data are acquired from the literature by curation staff and via electronic submission from laboratories. New expression data are made available on a daily basis. GXD is integrated with the Mouse Genome Database (MGD) to enable a combined analysis of genotype, expression, and phenotype data. In conjunction with the Gene Ontology project we build shared controlled vocabularies for biological processes, molecular functions and cellular components and assign those terms to mouse genes and their products. These classification schemes provide important new search parameters for expression data. Extensive and continuously refined interconnections with sequence databases and with databases from other species place the gene expression information in the larger biological and analytical context. GXD is accessible through the Mouse Genome Informatics web site at
http://www.informatics.jax.org/ or directly at
http://www.informatics.jax.org/menus/expression_menu.shtml.

GXD is supported by NIH grant HD33745. The Gene Ontology project is supported by NIH