Progress, and Applications
of the Human Genome Project
Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
In this issue...
Also available in pdf.
1997 Santa Fe Highlights
In the News
After the Genome Project: Understanding the Data
Survey Identifies Growing Need for Synchrotron Analyses
Structural Biology and Synchrotron Radiation: Evaluation of Resources and Needs (1997) is a report on the current status of biological uses and demands of synchrotron radiation in the United States. For this report, staff at the synchrotron radiation facilities and their user communities were surveyed, and a group of experienced structural biologists analyzed the data.
In evaluating what synchrotron facilities and support operations are needed and in anticipating future requirements for sustaining the exciting progress in structural biology, the BioSync Committee noted the expanded impact of structural biology in recent years. This expansion has led to an increase in the size and complexity of macromolecular structures being determined and in the difficulty of experiments being pursued. Structural biology is having a widening effect on such diverse fields as immunology, neurobiology, cell biology, virology, physiology, molecular biology, medicine, and biotechnology.
Recent advances in structural biology can be attributed to (1) methodological improvements that allow a vast array of cellular proteins to be cloned and expressed in quantities sufficient for structural studies, (2) use of cryocrystallography to prepare extremely stable crystals, and (3) availability of and technological innovations at synchrotron radiation facilities (see Envisioning the Proteome.) These factors have brought many more projects of high biological significance into the realm of structural biology. Without synchrotron sources, many of these new research projects could not have been undertaken.
The BioSync Committee reached the following main conclusions:
1997 BioSync Report
Last modified: Wednesday, October 29, 2003
Home * Contacts * Disclaimer
Document Use and Credits
Publications and webpages on this site were created by the U.S. Department of Energy Genome Program's Biological and Environmental Research Information System (BERIS). Permission to use these documents is not needed, but please credit the U.S. Department of Energy Genome Programs and provide the website http://genomics.energy.gov. All other materials were provided by third parties and not created by the U.S. Department of Energy. You must contact the person listed in the citation before using those documents.
Base URL: www.ornl.gov/hgmis
Site sponsored by the U.S. Department of Energy Office of Science, Office of Biological and Environmental Research, Human Genome Program