Progress, and Applications
of the Human Genome Project
Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
Human Genome News, January 1998; 9:(1-2)
On June 24, 1997, The Institute for Genomic Research (TIGR) announced termination of its relationship with its profit-making arm, Human Genome Sciences, Inc. Also on June 24, TIGR released 40 Mb of microbial genome data (http://www.tigr.org). In addition, TIGR released data from the Borrelia burgdorferi (completed) chromosome on July 25.
All data are accessible by anonymous ftp (http://ftp.tigr.org/). Users should log in as "anonymous" and provide their e-mail address as a password. The data also may be accessed through the Web (ftp://ftp.tigr.org/pub/data).
Searching the Data
TIGR's completed and published genomes are searchable through the TIGR site (http://www.tigr.org/tdb/mdb/mdb.html). A new BLAST service is now available at the National Center for Biotechnology Information for searching the incomplete microbial genomes, which are not yet accessible through GenBank or Entrez. TBLASTN (a user's protein query vs a six-frame translation of the microbial DNA sequences) uses the new gapped BLAST algorithm.
The South African National Bioinformatics Institute has put up a search engine for TIGR contigs and Sanger cosmids of Mycobacterium tuberculosis, finished and unfinished (http://www.sanbi.ac.za). In addition, a first pass at ORF-predicted sets can be used for searching.
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