Progress, and Applications
of the Human Genome Project
Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
Human Genome News, January 1998; 9:(1-2)
Lawrence Livermore National Laboratory (LLNL) Human Genome Center and Onyx Pharmaceuticals, Inc., recently signed an agreement to collaborate in developing automated, high-throughput methods for generating proteins from gene sequences. To help identify and characterize new therapeutic targets for Onyx’s current drug-screening programs, research will focus on genes known to play a causative role in cancers. Joanna Albala of LLNL and Robin Clark and Anthony Davies of Onyx are principal investigators in the collaboration.
LLNL brings to the collaboration the Integrated Molecular Analysis of Gene Expression (called I.M.A.G.E.) collection of arrayed cDNA libraries, along with the expertise and infrastructure for miniaturizing and automating biological sample handling. Onyx has developed expertise and reagents for expressing proteins using the baculovirus expression system and for purifying a wide variety of human proteins using epitope tags. Investigators expect the new system to reduce drug-development time by providing a ready source of proteins for assay development and drug screening.
The 2-year collaboration is the first at LLNL to be funded under the Biotechnology Strategic Targets for Alliances in Research (BioSTAR) project. BioSTAR provides for university matching of private-sector funding for biotechnology research.
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