Progress, and Applications
of the Human Genome Project
Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
Human Genome News, April-June 1996; 7(6)
Human Genome Project researchers reached the project's large-scale genetic-mapping goals with the publication of two maps in the March 14, 1996, issue of Nature: a dense genetic map of the laboratory mouse constructed by Eric Lander and colleagues at Whitehead Institute-MIT and a separate linkage map of the human genome by Jean Weissenbach's group at Généthon.
The mouse map [http://www.broad.mit.edu/] contains 7377 markers scattered along 20 pairs of chromosomes, or about 1 every 400,000 nucleotide bases. The human genetic map is composed entirely of 5264 microsatellite markers (1 every 0.7 cM) that can be assayed rapidly in large numbers by PCR.
With genetic maps for both human and mouse now essentially complete, the second phase of the Human Genome Project is concentrating on sequence-ready map production and large-scale sequencing projects.
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