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Human Genome News Archive Edition

Human Genome Quarterly, Spring 1989; 1(1)

Computer Scientists Join Molecular Biologists In Genome Workshop

Restriction mapping, crystallography, relational databases, and fifth-generation technology were among the topics discussed by an international panel of computer scientists and biologists at Argonne National Laboratory (ANL) on November 3-5, 1988.

The panel, which included experts from the United States, Europe, and Japan, addressed the question, "How can advanced computer technologies help meet the needs of researchers in biological sequencing?" The answers to this question formed the basis of a strategy document outlining how the Department of Energy might best allocate resources for the development of computational tools for biological sequencing projects.

The three-day meeting began with tutorials on genome sequencing and advanced computer technologies. Lively discussion followed the tutorials, with the panel members disagreeing on the relative merits of integrated vs heterogeneous databases. The participants agreed unanimously, however, that a set of model projects should be established to explore all facets of the problem. Several individual tools that should be explored as part of the model projects were identified, and these include:

• rapid analysis tools that would enable users to search a database quickly,
• dynamic simulation tools for structural analysis of cells and organisms, and
• improved pattern-recognition tools that would exploit logic programming techniques to aid in protein analysis.

Copies of the 72-page report, Proceedings of the Workshop on Advanced Computer Technologies and Biological Sequencing (ANL-88-45), are available from Gail W. Pieper, ANL.

Submitted by Gail W. Pieper
Senior Technical Editor, MCS Division
Argonne National Laboratory
Building 221, Argonne, IL 60439

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