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In this issue...

In the News
Countering Bioterrorism
Genomes to Life Program
TIGR Anthrax Sequencing
Chromosome 20 Sequence
Pufferfish, Poplar Sequence
Microarrays, Anthrax ID
Patrinos Wins Award as Distinguished Executive
Spinach DNA: Hope for Blind
TIGR Functional Genomics
DOE Medical Technologies
Protein Trinity, Disorder
Gene p53 Research
PROSPECT Prediction
Low Dose Radiation Program
Award for Microscope
Bio-Science News at National Labs
Microbial Genome Program

Special Meeting Report
Genes and Justice
GM Products
Genetic Discrimination
What are GM Organisms and Foods?

Web, Publications, Resources
Biosciences Online
DNA Files on Radio
Primer on DNA Basics
CD-ROM Wins Rave Review
Other Resources

Funding Information
GTL Program Announcements
US Genome-Related Research Funding

Meeting Calendars & Acronyms
Genome and Biotechnology Meetings
Training Courses and Workshops
Acronyms

HGN archives and subscriptions
Human Genome Project Information home

Minireviews on Gene p53 Published

The p53 gene, found on chromosome 17, is a tumor-suppressor gene. In the cell, the p53 protein binds DNA at specific locations and stimulates another gene to produce a protein called p21. In turn, p21 suppresses a division-stimulating protein (cdk2) to prevent the cell from passing through to the next stage of cell division. When p53 is mutant and can no longer bind DNA effectively, the p21 protein is not available to act as the “stop signal” for cell division. Thus cells may divide uncontrollably and form tumors. The p53 gene plays a key role in the pathogenesis or etiology of human cancers and clearly is an important component in a network of events that culminate in tumor formation. Mutations in p53 are found in most tumor types.

Some articles on p53 appear in the May 18, 2001, issue of European Journal of Biochemistry 268 (10). The journal contains several minireviews commissioned and organized by Ettore Appella (NIH National Cancer Institute) and Carl Anderson (Brookhaven National Laboratory). The articles are as follows:

• “Modulation of p53 Function in Cellular Regulation,” introduction by Appella.
• “Post-Translational Modifications and Activation of p53 by Genotoxic Stresses,” by Appella and Anderson.
• “Regulation of p53 Localization,” by Shun-Hsin Liang (Pennsylvania State University) and Michael Clarke (University of Michigan Medical Center).
• “P300/CBP/p53 Interaction and Regulation of the p53 Response,” by Steven Grossman (Brigham and Women’s Hospital and Harvard Medical School).
• “Regulation of Cellular Senescence by 53,” by Koji Itahan, Goberdhan Dimri, and Judith Campisi (all at Lawrence Berkeley National Laboratory).

The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v12n1-2).