Progress, and Applications
of the Human Genome Project
Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
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In the News
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Imaging Biological Structures
Because molecular shape often provides clues to function in biological systems, obtaining a detailed knowledge of structure can help elucidate the basic principles of cell and organism function and the role of faulty structures in disease. A broad collection of structural data will provide valuable information beyond that available from individual structures and will have applications in the life sciences, biotechnology, and medicine.
Key advances making structural genomics research possible include the availability of synchrotrons and high-field NMR (nuclear magnetic resonance) instruments; the MAD (multiwavelength anomalous diffraction) method of phase determination; high-throughput cloning and recombinant expression; a flood of information from genome sequencing projects; and bioinformatics methods for protein-fold assignment, model building, and function prediction.
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Last modified: Wednesday, October 29, 2003
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