Progress, and Applications
of the Human Genome Project
Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
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DOE '99 Oakland Highlights
In the News
Web, Other Resources, Publications
The EcoCyc project was conceived in 1990 by Peter Karp (then at SRI International) and Monica Riley (Marine Biological Laboratory) to provide a central, integrative resource for the quickly changing knowledge about E.coli's genes and metabolism. Karp's group developed Pathway Tools, a software environment that included but went beyond genome sequence data by integrating richly curated information on gene function and pathways. Riley's group searched the biomedical literature for material on E.coli enzymes and pathways. An early task was to determine what to gather about each enzyme and pathway and to design a database schema that would accommodate that information. Riley published a system for categorizing E.coli genes according to their function; this and other similar systems have since been used by genome project researchers to classify their annotated genes. Kenneth Rudd (National Center for Biotechnology Information) contributed his collection of all known E.coli DNA sequences and assembled them into an ordered set of maximal sequences that were pinned to the Kohara physical restriction map of the E.coli chromosome. After Fred Blattner's group at the University of Wisconsin completed E.coli's DNA sequence, the data were integrated into EcoCyc.
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Last modified: Wednesday, October 29, 2003
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