DOE '99 Oakland Highlights
Meeting Intro
HGP Progress, Challenges
Joint Genome Institute
JGI Facility Opening
Sequencing
Device Speeds Sequencing
Chromosome 19 Genes
Functional Genomics
Sample Prep System
Informatics
Education & Bioethics
Microbial Genomes
Next Meeting Feb. 2000

Genome Project
Accelerated Timetable
FY1999 Budgets
JGI Refits Facility
Progress

In the News 
 Drosophila Near Completion
Directors, Researchers Receive Awards
Chromosomes 21, 22 Near Finish
Human MHC Region Sequenced
Mouse Probes Aid Mapping
Genetic Testing Committee
DOE Labs & Biomedicine
Biomedical Engineering Proposals
Drug Firms Create SNP Resource
SBIR 1999 Awards
HUGO News
1999 Hollaender Winners

Microbial Genomics 
EcoCyc Database for E. coli
Developing EcoCyc
Thermotoga Sequence
Clostridium Sequenced
Microbial Gene Finder
Neisseria Sequence
Microbial Web Sites

Ethical, Legal, and Social Issues
Education, Counseling Foundation
 ELSI Studies
ELSI Retrospective
Protecting Privacy

Informatics 
MGI 2.2 Released
DNA Repository

Web, Other Resources, Publications 
Metabolic Pathways
New Staden Package
PDB Newsletter
Polymorphism Database
Bacterial Protein Database
DOE BER Publications
HGP Information Web
Biotechnology Business Webs
Behavioral Genetics
Office of Science Reports
Articles on Genetics

Funding 
Genome Research Funding

Meeting Calendars & Acronyms 
Genome & Biotech Meetings 
Training Courses & Workshops 
Acronyms 

HGN archives & subscriptions 
HGP Information home

In the News

New Mouse Probes Aid Gene Mapping

A team led by Julie Korenberg (Cedars-Sinai Medical Center, Los Angeles) has produced a family ofDNA probes that "light up" mouse chromosome sites under fluorescence microscopy. The markers, spaced at an average 19 million bases throughout the 3billion bases of the mouse genome, aid researchers who are hunting for mouse counterparts of human genes. The work is described in the May 1999 cover article of Genome Research.

The mouse is a favorite research model for understanding human biology, and researchers are finding more and more corresponding genes on human and mouse chromosomes. Unlike human chromosomes, however, mouse chromosomes have few distinguishing features that help cytogeneticists hunt for particular disease genes. The new markers thus far have led researchers to the mouse counterpart of the human Down's syndrome region.

The DNA resource consists of 157 BAC clones, each an identifier of specific bands or band borders, with 42 linked to genetic markers from the centromeric and telomeric ends of the Whitehead-MIT recombinational maps. Inclusion of BAC clones containing markers from the ends of genetic maps is expected to facilitate development of an integrated view of mouse cytogenetic, genetic, and physical maps.

The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v10n3-4).