Genome Sequencing Technologies and Resources Section 

DOE Human Genome Program Contractor-Grantee Workshop VII 
January 12-16, 1999  Oakland, CA

30. Co-Development of High Throughput Sequencing Systems with the Joint Genome Institute 

Eric Lander 
Whitehead Institute, Cambridge, Massachusetts 
lander@wi.mit.edu 

The Joint Genome Institute (JGI) and Whitehead Institute will establish a Co-Development Program to produce an automated DNA sequencing production line with a capacity of 200 Mb per year. The production line will consist of: 

  • Automated devices for sampling processing. The devices are based on existing systems used at Whitehead, but are comprehensively re-designed and re-engineered for the requirements of a factory production line. The design involves a universal "base system" that is customized for four specific applications. The devices will be constructed by Intelligent Automation Systems (IAS), with which Whitehead worked successfully on the construction of its Genomatron system.
  • Informatics system. The accompanying informatics system will consist of a comprehensive database, workflow pipeline, and analytical software.
Production lines will be installed at both JGI and Whitehead. The Co-Development Program will implement, evaluate, and modify the production line. The evaluation will include using the system to sequence a total of 20 Mb of genomic sequence from human chromosome 19, consisting of 10 Mb at Whitehead and 10 Mb at JGI. 
 
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