Sequencing  

Advanced Detectors for Mass Spectrometry 
W.H. Benner and J.M. Jaklevic 
Lawrence Berkeley National Laboratory, Berkeley, California 

Mass Spectrometer for Human Genome Sequencing 
Chung-Hsuan Chen 
Oak Ridge National Laboratory, Oak Ridge, Tennessee 

Genomic Sequence Comparisons 
George Church 
Harvard Medical School, Boston, Massachusetts 

A PAC/BAC End-Sequence Data Resource for Sequencing the Human Genome: A 2-Year Pilot Study 
Pieter de Jong 
Roswell Park Cancer Institute, Buffalo, New York 

Multiple-Column Capillary Gel Electrophoresis 
Norman Dovichi 
University of Alberta, Edmonton, Canada 

DNA Sequencing with Primer Libraries 
John J. Dunn and F. William Studier 
Brookhaven National Laboratory, Upton, New York 

Rapid Preparation of DNA for Automated Sequencing 
John J. Dunn and F. William Studier 
Brookhaven National Laboratory, Upton, New York 

A PAC/BAC End-Sequence Database for Human Genomic Sequencing 
Glen A. Evans 
University of Texas Southwestern Medical Center, Dallas, Texas 

Automated DNA Sequencing by Parallel Primer Walking 
Glen A. Evans 
University of Texas Southwestern Medical Center, Dallas, Texas 

*Parallel Triplex Formation as Possible Approach for Suppression of DNAViruses Reproduction 
V.L. Florentiev 
Russian Academy of Sciences, Moscow, Russia 

Advanced Automated Sequencing Technology: Fluorescent Detection for Multiplex DNA Sequencing 
Raymond F. Gesteland 
University of Utah, Salt Lake City, Utah 

Resource for Molecular Cytogenetics 
Joe Gray and Daniel Pinkel 
University of California, San Francisco 

DNA Sample Manipulation and Automation 
Trevor Hawkins 
Whitehead Institute and Massachusetts Institute of Technology, Cambridge, Massachusetts 

Construction of a Genome-Wide Characterized Clone Resource for Genome Sequencing 
Leroy Hood, MarkD. Adams,¹ and Melvin Simon² 
University of Washington, Seattle 
¹The Institute for Genomic Research, Rockville, Maryland 
²California Institute of Technology, Pasadena, California 

DNA Sequencing Using Capillary Electrophoresis 
Barry L. Karger 
Northeastern University, Boston, Massachusetts 

Ultrasensitive Fluorescence Detection of DNA 
Richard A. Mathies and Alexander N. Glazer 
University of California, Berkeley 

Joint Human Genome Program Between Argonne National Laboratory and the Engelhardt Institute of Molecular Biology 
Andrei Mirzabekov 
Argonne National Laboratory, Argonne, Illinois, and Engelhardt Institute of Molecular Biology, Moscow, Russia 

High-Throughput DNA Sequencing: SAmple SEquencing (SASE) Analysis as a Framework for Identifying Genes and Complete Large-Scale Genomic Sequencing 
Robert K. Moyzis 
Los Alamos National Laboratory, Los Alamos, New Mexico 

One-Step PCR Sequencing 
Barbara Ramsay Shaw 
Duke University, Durham, North Carolina 

Automation of the Front End of DNA Sequencing 
Lloyd M. Smith and Richard A. Guilfoyle 
University of Wisconsin, Madison 

High-Speed DNA Sequence Analysis by Matrix-Assisted Laser Desorption Mass Spectrometry 
Lloyd M. Smith 
University of Wisconsin, Madison 

Analysis of Oligonucleotide Mixtures by Electrospray Ionization-Mass Spectrometry 
Richard D. Smith 
Pacific Northwest National Laboratory, Richland, Washington 

High-Speed Sequencing of Single DNA Molecules in the Gas Phase by FTICRMS 
Richard D. Smith 
Pacific Northwest National Laboratory, Richland, Washington 

Characterization and Modification of DNA Polymerases for Use in DNA Sequencing 
Stanley Tabor 
Harvard University, Boston, Massachusetts 

Modular Primers for DNA Sequencing 
Levy Ulanovsky^1,2  
1Argonne National Laboratory, Argonne, Illinois 
²Weizmann Institute of Science, Rehovot, Israel 

Time-of-Flight Mass Spectroscopy of DNA for Rapid Sequence 
Peter Williams 
Arizona State University, Tempe, Arizona 

Development of Instrumentation for DNA Sequencing at a Rate of 40 Million Bases Per Day 
Edward S. Yeung 
Iowa State University, Ames, Iowa 

Mapping  

Resolving Proteins Bound to Individual DNA Molecules 
David Allison and Bruce Warmack 
Oak Ridge National Laboratory, Oak Ridge, Tennessee 

*Improved Cell Electrotransformation by Macromolecules 
Alexandre S. Boitsov 
St. Petersburg State Technical University, St. Petersburg, Russia 

Overcoming Genome Mapping Bottlenecks 
Charles R. Cantor 
Boston University, Boston, Massachusetts 

Preparation of PAC Libraries 
Pieter J. de Jong 
Roswell Park Cancer Institute, Buffalo, New York 

Chromosomes by Third-Strand Binding 
Jacques R. Fresco 
Princeton University, Princeton, New Jersey 

Chromosome Region-Specific Libraries for Human Genome Analysis 
Fa-Ten Kao 
Eleanor Roosevelt Institute for Cancer Research, Denver, Colorado 

*Identification and Mapping of DNA-Binding Proteins Along Genomic DNA by DNA-Protein Crosslinking 
V.L. Karpov 
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia 

A PAC/BAC Data Resource for Sequencing Complex Regions of the Human Genome:  A 2-Year Pilot Study 
Julie R. Korenberg 
Cedars Sinai Medical Center, Los Angeles, California 

Mapping and Sequencing of the Human  X Chromosome 
D.L. Nelson 
Baylor College of Medicine, Houston, Texas 

*Sequence-Specific Proteins Binding to the Repetitive Sequences of High Eukaryotic Genome 
Olga Podgornaya 
Institute of Cytology, Russian Academy of Sciences, 
St. Petersburg, Russia 

*Protein-Binding DNA Sequences 
O.L. Polanovsky 
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia 

*Development of Intracellular Flow Karyotype Analysis 
A.I. Poletaev 
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia 

Mapping and Sequencing with BACs and Fosmids 
Melvin I. Simon 
California Institute of Technology, Pasadena, California 

Towards a Globally Integrated, Sequence-Ready BAC Map of the Human Genome 
Melvin I. Simon 
California Institute of Technology, Pasadena, California 

Generation of Normalized and Subtracted cDNA Libraries to Facilitate Gene Discovery 
Marcelo Bento Soares 
Columbia University, New York, New York 

Mapping in Man-Mouse Homology Regions 
Lisa Stubbs 
Oak Ridge National Laboratory, Oak Ridge, Tennessee 

Positional Cloning of Murine Genes 
Lisa Stubbs 
Oak Ridge National Laboratory, Oak Ridge, Tennessee 

Human Artificial Episomal Chromosomes (HAECS) for Building Large Genomic Libraries 
Jean-Michel H. Vos 
University of North Carolina, Chapel Hill 

*Cosmid and cDNA Map of a Human Chromosome 13q14 Region Frequently Lost atB Cell Chronic Lymphocytic Leukemia 
N.K. Yankovsky 
N.I. Vavilov Institute of General Genetics, Moscow, Russia 

Informatics  

BCM Server Core 
Daniel Davison 
Baylor College of Medicine, Houston, Texas 

A Freely Sharable Database-Management System Designed for Use in Component-Based, Modular Genome Informatics Systems 
Nathan Goodman 
The Jackson Laboratory, Bar Harbor, Maine 

A Software Environment for Large-Scale Sequencing 
Mark Graves 
Baylor College of Medicine, Houston, Texas 

Generalized Hidden Markov Models for Genomic Sequence Analysis 
David Haussler 
University of California, Santa Cruz 

Identification, Organization, and Analysis of Mammalian Repetitive DNA Information 
Jerzy Jurka 
Genetic Information Research Institute, Palo Alto, California 

*TRRD, GERD and COMPEL: Databases on Gene-Expression Regulation as a Tool for Analysis of Functional Genomic Sequences 
N.A. Kolchanov 
Institute of Cytology and Genetics, Novosibirsk, Russia 

Data-Management Tools for Genomic Databases 
Victor M. Markowitz and I-Min A. Chen 
Lawrence Berkeley National Laboratory, Berkeley, California 

The Genome Topographer: System Design 
T. Marr 
Cold Spring Harbor Laboratory, Cold Spring Harbor, NewYork 

A Flexible Sequence Reconstructor for LargeScale DNA Sequencing: A Customizable Software System for Fragment Assembly 
Gene Myers 
University of Arizona, Tucson 

The Role of Integrated Software and Databases in Genome Sequence Interpretation and Metabolic Reconstruction 
Ross Overbeek 
Argonne National Laboratory, Argonne, Illinois 

Database Transformations for Biological Applications 
G. Christian Overton, Susan B. Davidson, and 
Peter Buneman 
University of Pennsylvania, Philadelphia 

Las Vegas Algorithm for Gene Recognition: Suboptimal and Error-Tolerant Spliced Alignment 
Pavel A. Pevzner 
University of Southern California, Los Angeles, California 

Foundations for a Syntactic Pattern-Recognition System for Genomic DNA Sequences: Languages, Automata, Interfaces, and Macromolecules 
David B. Searls 
SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 

Analysis and Annotation of Nucleic Acid Sequence 
David J. States 
Washington University, St. Louis, Missouri 

Gene Recognition, Modeling, and Homology Search in GRAIL and genQuest 
Edward C. Uberbacher 
Oak Ridge National Laboratory, Oak Ridge, Tennessee 

Informatics Support for Mapping in Mouse-Human Homology Regions 
Edward Uberbacher 
Oak Ridge National Laboratory, Oak Ridge, Tennessee 

SubmitData: Data Submission to Public Genomic Databases 
Manfred D. Zorn 
Lawrence Berkeley National Laboratory, University of 
California, Berkeley 

ELSI  

The Human Genome: Science and the Social Consequences; Interactive Exhibits and Programs on Genetics and the Human Genome 
Charles C. Carlson 
The Exploratorium, San Francisco, California 

Documentary Series for Public Broadcasting 
Graham Chedd and Noel Schwerin 
Chedd-Angier Production Company, Watertown, Massachusetts 

Human Genome Teacher Networking Project 
Debra L. Collins and R. Neil Schimke 
University of Kansas Medical Center, Kansas City, Kansas 

Human Genome Education Program 
Lane Conn 
Stanford Human Genome Center, Palo Alto, California 

Your World/Our World­Biotechnology & You: Special Issue on the Human Genome Project 
Jeff Davidson and Laurence Weinberger 
Pennsylvania Biotechnology Association, State College, Pennsylvania 

The Human Genome Project and Mental Retardation: An Educational Program 
Sharon Davis 
The Arc of the United States, Arlington, Texas 

Pathways to Genetic Screening: Molecular Genetics Meets the High-Risk Family 
Troy Duster 
University of California, Berkeley 

Intellectual Property Issues in Genomics 
Rebecca S. Eisenberg 
University of Michigan Law School, Ann Arbor, Michigan 

AAAS Congressional Fellowship Program 
Stephen Goodman 
The American Society of Human Genetics, Bethesda, Maryland 

A Hispanic Educational Program for Scientific, Ethical, Legal, and Social Aspects of the Human Genome Project 
Margaret C. Jefferson and Mary Ann Sesma¹ 
California State University 
¹Los Angeles Unified School District, Los Angeles, California 

Implications of the Geneticization of Health Care for Primary Care Practitioners 
Mary B. Mahowald 
University of Chicago, Chicago, Illinois 

Nontraditional Inheritance: Genetics and the Nature of Science; Instructional Materials for High School Biology 
Joseph D. McInerney and B. Ellen Friedman 
Biological Sciences Curriculum Study, Colorado Springs, Colorado 

The Human Genome Project: Biology, Computers, and Privacy: Development of Educational Materials for High School Biology 
Joseph D. McInerney and Lynda B. Micikas 
Biological Sciences Curriculum Study, Colorado Springs, Colorado 

Involvement of High School Students in Sequencing the Human Genome 
Maureen M. Munn, Maynard V. Olson, and Leroy Hood 
University of Washington, Seattle 

The Gene Letter: A Newsletter on Ethical, Legal, and Social Issues in Genetics for Interested Professionals and Consumers 
Philip J. Reilly, Dorothy C. Wertz, and Robin J.R. Blatt 
The Shriver Center for Mental Retardation, Waltham, 
Massachusetts 

The DNA Files: A Nationally Syndicated Series of Radio Programs on the Social Implications of Human Genome Research and Its Applications 
Bari Scott 
Genome Radio Project, KPFAFM, Berkeley, California 

Communicating Science in Plain Language: The Science+Literacy for Health: Human Genome Project 
Maria Sosa, Judy Kass, and Tracy Gath 
American Association for the Advancement of Science, Washington, D.C. 

The Community College Initiative 
Sylvia J. Spengler and Laurel Egenberger 
Lawrence Berkeley National Laboratory, Berkeley, California 

Genome Educators 
Sylvia Spengler and Janice Mann 
Lawrence Berkeley National Laboratory, Berkeley, California 

Getting the Word Out on the Human Genome Project: A Course for Physicians 
Sara L. Tobin and Ann Boughton¹ 
Stanford University, Palo Alto, California 
¹Thumbnail Graphics, Oklahoma City, Oklahoma 

The Genetics Adjudication Resource Project 
Franklin M. Zweig 
Einstein Institute for Science, Health, and the Courts, Bethesda, Maryland 

Infrastructure   

Alexander Hollaender Distinguished Postdoctoral Fellowships 
Linda Holmes and Eugene Spejewski 
Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee 

Human Genome Management Information System 
Betty K. Mansfield and John S. Wassom 
Oak Ridge National Laboratory, Oak Ridge, Tennessee 

Human Genome Program Coordination 
Sylvia J. Spengler 
Lawrence Berkeley National Laboratory, Berkeley, California 

Support of Human Genome Program Proposal Reviews 
Walter Williams 
Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee 

Former Soviet Union Office of Health and Environmental Research Program 
James Wright 
Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee 

SBIR 

1996 Phase I  

An Engineered RNA/DNA Polymerase to Increase Speed and Economy of DNA Sequencing 
Mark W. Knuth 
Promega Corporation, Madison, Wisconsin 

Directed Multiple DNA Sequencing and  Expression Analysis by Hybridization 
Gualberto Ruano 
BIOS Laboratories, Inc., New Haven, Connecticut 

1996 Phase II  

A Graphical Ad Hoc Query Interface Capable of Accessing Heterogeneous Public Genome Databases 
Joseph Leone 
CyberConnect Corporation, Storrs, Connecticut 

Low-Cost Automated Preparation of Plasmid, Cosmid, and Yeast DNA 
William P. MacConnell 
MacConnell Research Corporation, San Diego, California 

GRAIL-GenQuest: A Comprehensive Computational Framework for DNA Sequence Analysis 
Ruth Ann Manning 
ApoCom, Inc., Oak Ridge, Tennessee 

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