Although the genome program is contributing fundamental
information about the structure of chromosomes and
genes, other types of knowledge are required to understand how genes and their products function. Three-dimensional protein structure studies are still essential because structure cannot be predicted fully from its encoded DNA sequence.
To enhance these and other studies, DOE builds and maintains structural biology user facilities that enable scientists to gain an understanding of relationships between biological structures and their functions, study disease processes, develop new pharmaceuticals, and conduct basic research in molecular biology and environmental processes. These resources are used heavily by both academic and private-sector scientists.
Other important resources available to the research
community include the clone libraries developed in the National Laboratory
Gene Library Project and distributed worldwide, the GRAIL Online Sequence
Interpretation Service, and the Mouse Genetics Research Facility.
Argonne National Laboratory
The 1997 DOE Human Genome Program Report is a two-part
report published in 1997 to reflect research and progress in the U.S. Department
of Energy Human Genome Program from 1994 through 1996, with specified updates
made just before publication. Part 1 is the program overview and
report on progress, and Part 2 consists of 1996 research abstracts.