Putative-Gene Classification. The figure depicts the functional classification of putative genes identified in a 1.02-Mb region on the long arm of human chromosome 19. Analysis of the completed sequence between markers D19S208 and COX7A1 revealed 43 open reading frames (ORFs) or putative genes. (An ORF is a DNA region containing specific sequences that signal the beginning and ending of a gene.)
Thirty of these putative genes were found to have sequence similarities to a wide variety of known genes or proteins, including some involved in transcription, cell adhesion and signaling, and metabolism. Many appear to be related functionally to such known proteins as the GTPase activating proteins or the ETS family of transcription factors. Others seem to be new members of existing gene families, for example, the mRNA splicing factor, or of such pseudogenes as the elongation factor Tu.
In addition to those that could be classified, 13 novel genes were identified, including one with high similarity to a predicted ORF of unknown function in the roundworm Caenorhabditis elegans.
The 1997 DOE Human Genome Program Report is a two-part
report published in 1997 to reflect research and progress in the U.S. Department
of Energy Human Genome Program from 1994 through 1996, with specified updates
made just before publication. Part 1 is the program overview and
report on progress, and Part 2 consists of 1996 research abstracts.