FISH Mapping on DNA Fibers. The fluorescence microscope reveals several individual cloned DNA fibers from yeast artificial chromosomes (YACs, in blue) after molecular combing to attach and stretch the DNA molecules across a glass microscope slide. Also shown are the locations of two P1 clones, labeled green and red, mapped onto the YAC fibers using FISH. Digital imaging technology can be used to assemble physical maps of chromosomes with a resolution of about 3 to 5 kilobases.
The 1997 DOE Human Genome Program Report is a two-part report published in 1997 to reflect research and progress in the U.S. Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 1 is the program overview and report on progress, and Part 2 consists of 1996 research abstracts.